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- W1999404507 abstract "Summary Elevated plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1), also named serpin E1, are encountered in patients with thrombophilia, atherosclerosis, septicemia and the metabolic syndrome and may be associated with an increased risk of complications. Expression of PAI-1 is increased by inflammatory stimuli and decreased by statins, drugs widely used in patients with cardiovascular disease. Increased expression of PAI-1 by inflammatory stimuli is mediated by a large variety of signal transduction pathways, which include the NF-κB and MAP kinase pathways. The downregulating effect of statins on PAI-1 expression is dependent on the inhibition of Rho family proteins and may involve an activation of PI-3 kinase/Akt signaling pathways. In this review we summarize the findings on the effect of inflammation and statins on PAI-1 expression." @default.
- W1999404507 created "2016-06-24" @default.
- W1999404507 creator A5047746564 @default.
- W1999404507 date "2008-01-01" @default.
- W1999404507 modified "2023-09-27" @default.
- W1999404507 title "Regulation of plasminogen activator inhibitor type 1 gene expression by inflammatory mediators and statins" @default.
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- W1999404507 doi "https://doi.org/10.1160/th08-04-0269" @default.
- W1999404507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19132219" @default.
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