FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999408921> ?p ?o ?g. }

• W1999408921 endingPage "89" @default.
• W1999408921 startingPage "85" @default.
• W1999408921 abstract "Allantoin is the major oxidation product of urate in humans and is a potential biomarker of oxidative stress. Several methods are used to measure allantoin in biological samples but they have inherent issues that can include lack of specificity and sensitivity, difficulty in sample preparation, or artefactual generation of allantoin. We have developed a method for measuring allantoin using hydrophilic liquid chromatography with stable isotope dilution tandem mass spectrometry (HILIC–MS/MS). It was validated for measuring allantoin in plasma, synovial fluid and urine from human subjects. The limit of quantification was determined to be 10 fmol and the assay displayed excellent linearity for the wide range of concentrations found in clinical samples. Relative standard deviations were <5% for between-day and <7% for within-day variation. Accuracy was between 100% and 104%. Concentrations of allantoin in plasma of healthy controls (2.0 μM; interquartile range 1.4–3.6 μM, n = 35) was significantly lower (p < 0.001) than that in plasma from patients with rheumatoid arthritis (3.7 μM; IQR 3.0–5.6 μM, n = 43) and in synovial fluid of patients with gout (3.3 μM; IQR 2.8–5.8 μM, n = 10). This newer HILIC–MS/MS method is a simple and highly sensitive assay for detection of allantoin. It can be used to assess the level of oxidative stress in human pathologies." @default.
• W1999408921 created "2016-06-24" @default.
• W1999408921 creator A5041601466 @default.
• W1999408921 creator A5043093028 @default.
• W1999408921 creator A5061552694 @default.
• W1999408921 date "2012-04-01" @default.
• W1999408921 modified "2023-09-26" @default.
• W1999408921 title "Detection of allantoin in clinical samples using hydrophilic liquid chromatography with stable isotope dilution negative ion tandem mass spectrometry" @default.
• W1999408921 cites W1905838994 @default.
• W1999408921 cites W1966438194 @default.
• W1999408921 cites W1971727064 @default.
• W1999408921 cites W1977486634 @default.
• W1999408921 cites W1983878756 @default.
• W1999408921 cites W1998973832 @default.
• W1999408921 cites W2000136688 @default.
• W1999408921 cites W2029040624 @default.
• W1999408921 cites W2043617374 @default.
• W1999408921 cites W2045432481 @default.
• W1999408921 cites W2047096714 @default.
• W1999408921 cites W2048388868 @default.
• W1999408921 cites W2049216839 @default.
• W1999408921 cites W2067520366 @default.
• W1999408921 cites W2073003425 @default.
• W1999408921 cites W2077828570 @default.
• W1999408921 cites W2079739815 @default.
• W1999408921 cites W2093734025 @default.
• W1999408921 cites W2101391992 @default.
• W1999408921 cites W2118452417 @default.
• W1999408921 cites W2121626096 @default.
• W1999408921 cites W2124639061 @default.
• W1999408921 cites W2135419812 @default.
• W1999408921 cites W2144311270 @default.
• W1999408921 cites W2149919415 @default.
• W1999408921 cites W2162234541 @default.
• W1999408921 cites W1974263330 @default.
• W1999408921 doi "https://doi.org/10.1016/j.jchromb.2012.02.009" @default.
• W1999408921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22398212" @default.
• W1999408921 hasPublicationYear "2012" @default.
• W1999408921 type Work @default.
• W1999408921 sameAs 1999408921 @default.
• W1999408921 citedByCount "25" @default.
• W1999408921 countsByYear W19994089212012 @default.
• W1999408921 countsByYear W19994089212013 @default.
• W1999408921 countsByYear W19994089212014 @default.
• W1999408921 countsByYear W19994089212015 @default.
• W1999408921 countsByYear W19994089212016 @default.
• W1999408921 countsByYear W19994089212017 @default.
• W1999408921 countsByYear W19994089212018 @default.
• W1999408921 countsByYear W19994089212019 @default.
• W1999408921 countsByYear W19994089212020 @default.
• W1999408921 countsByYear W19994089212021 @default.
• W1999408921 countsByYear W19994089212022 @default.
• W1999408921 countsByYear W19994089212023 @default.
• W1999408921 crossrefType "journal-article" @default.
• W1999408921 hasAuthorship W1999408921A5041601466 @default.
• W1999408921 hasAuthorship W1999408921A5043093028 @default.
• W1999408921 hasAuthorship W1999408921A5061552694 @default.
• W1999408921 hasConcept C116817701 @default.
• W1999408921 hasConcept C119128265 @default.
• W1999408921 hasConcept C142724271 @default.
• W1999408921 hasConcept C162356407 @default.
• W1999408921 hasConcept C171679685 @default.
• W1999408921 hasConcept C179998833 @default.
• W1999408921 hasConcept C185592680 @default.
• W1999408921 hasConcept C204787440 @default.
• W1999408921 hasConcept C2776073210 @default.
• W1999408921 hasConcept C2776164576 @default.
• W1999408921 hasConcept C2776268809 @default.
• W1999408921 hasConcept C2779881121 @default.
• W1999408921 hasConcept C31827203 @default.
• W1999408921 hasConcept C43617362 @default.
• W1999408921 hasConcept C55493867 @default.
• W1999408921 hasConcept C64489805 @default.
• W1999408921 hasConcept C71043704 @default.
• W1999408921 hasConcept C71924100 @default.
• W1999408921 hasConceptScore W1999408921C116817701 @default.
• W1999408921 hasConceptScore W1999408921C119128265 @default.
• W1999408921 hasConceptScore W1999408921C142724271 @default.
• W1999408921 hasConceptScore W1999408921C162356407 @default.
• W1999408921 hasConceptScore W1999408921C171679685 @default.
• W1999408921 hasConceptScore W1999408921C179998833 @default.
• W1999408921 hasConceptScore W1999408921C185592680 @default.
• W1999408921 hasConceptScore W1999408921C204787440 @default.
• W1999408921 hasConceptScore W1999408921C2776073210 @default.
• W1999408921 hasConceptScore W1999408921C2776164576 @default.
• W1999408921 hasConceptScore W1999408921C2776268809 @default.
• W1999408921 hasConceptScore W1999408921C2779881121 @default.
• W1999408921 hasConceptScore W1999408921C31827203 @default.
• W1999408921 hasConceptScore W1999408921C43617362 @default.
• W1999408921 hasConceptScore W1999408921C55493867 @default.
• W1999408921 hasConceptScore W1999408921C64489805 @default.
• W1999408921 hasConceptScore W1999408921C71043704 @default.
• W1999408921 hasConceptScore W1999408921C71924100 @default.
• W1999408921 hasLocation W19994089211 @default.
• W1999408921 hasLocation W19994089212 @default.
• W1999408921 hasOpenAccess W1999408921 @default.
• W1999408921 hasPrimaryLocation W19994089211 @default.
• W1999408921 hasRelatedWork W1973119017 @default.

• next