FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999412042> ?p ?o ?g. }

• W1999412042 endingPage "235" @default.
• W1999412042 startingPage "222" @default.
• W1999412042 abstract "We examined whether Sema3A, which is upregulated at the site of spinal cord injury, exerts a direct effect on axons. We used ASNKL peptide that prevents specifically the inhibitory effect of Sema3A on L1/Neuropilin1 (Nrp1)-expressing axons. In the naïve mouse spinal cord, L1 is located on a subset of corticospinal axons, whereas Nrp1 is barely detectable. After contusion injury, Nrp1 is found on L1-negative immune cells, whereas its expression does not increase on severed axons. L1-expressing axons sprout extensively into the lesion site but no difference in axon density could be detected in the lesion area of mice treated with ASNKL. In agreement, these mice did not recover a better motor function than controls. Similarly, culture of neurons sensitive to ASNKL on cryosections of lesioned spinal cords revealed no effect of Sema3A. Our data indicate a limited direct effect of Sema3A on axonal growth at the site of a contusion injury, and suggest that alternative mechanisms underlie positive effects of Sema3A inhibition on motor recovery." @default.
• W1999412042 created "2016-06-24" @default.
• W1999412042 creator A5005154709 @default.
• W1999412042 creator A5030344996 @default.
• W1999412042 creator A5084350482 @default.
• W1999412042 creator A5085034433 @default.
• W1999412042 date "2008-02-01" @default.
• W1999412042 modified "2023-10-06" @default.
• W1999412042 title "Modulating Sema3A signal with a L1 mimetic peptide is not sufficient to promote motor recovery and axon regeneration after spinal cord injury" @default.
• W1999412042 cites W1558748452 @default.
• W1999412042 cites W1560041527 @default.
• W1999412042 cites W1566611926 @default.
• W1999412042 cites W1604510112 @default.
• W1999412042 cites W1963657135 @default.
• W1999412042 cites W1968074435 @default.
• W1999412042 cites W1969137460 @default.
• W1999412042 cites W1970901436 @default.
• W1999412042 cites W1980251112 @default.
• W1999412042 cites W1982628120 @default.
• W1999412042 cites W1983325630 @default.
• W1999412042 cites W1983400501 @default.
• W1999412042 cites W1992540841 @default.
• W1999412042 cites W1994088328 @default.
• W1999412042 cites W1997937844 @default.
• W1999412042 cites W2000762378 @default.
• W1999412042 cites W2003675005 @default.
• W1999412042 cites W2007011517 @default.
• W1999412042 cites W2008265159 @default.
• W1999412042 cites W2009329082 @default.
• W1999412042 cites W2026960985 @default.
• W1999412042 cites W2036380584 @default.
• W1999412042 cites W2037590378 @default.
• W1999412042 cites W2040496717 @default.
• W1999412042 cites W2041700814 @default.
• W1999412042 cites W2046569869 @default.
• W1999412042 cites W2050300529 @default.
• W1999412042 cites W2055079351 @default.
• W1999412042 cites W2060108012 @default.
• W1999412042 cites W2062937749 @default.
• W1999412042 cites W2072583908 @default.
• W1999412042 cites W2078936926 @default.
• W1999412042 cites W2081841141 @default.
• W1999412042 cites W2093788761 @default.
• W1999412042 cites W2099149147 @default.
• W1999412042 cites W2100976322 @default.
• W1999412042 cites W2101110142 @default.
• W1999412042 cites W2102147520 @default.
• W1999412042 cites W2103562436 @default.
• W1999412042 cites W2104086209 @default.
• W1999412042 cites W2104968232 @default.
• W1999412042 cites W2108464868 @default.
• W1999412042 cites W2121388820 @default.
• W1999412042 cites W2131860275 @default.
• W1999412042 cites W2139128003 @default.
• W1999412042 cites W2141767464 @default.
• W1999412042 cites W2147149841 @default.
• W1999412042 cites W2165871774 @default.
• W1999412042 doi "https://doi.org/10.1016/j.mcn.2007.09.009" @default.
• W1999412042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2259383" @default.
• W1999412042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17997325" @default.
• W1999412042 hasPublicationYear "2008" @default.
• W1999412042 type Work @default.
• W1999412042 sameAs 1999412042 @default.
• W1999412042 citedByCount "17" @default.
• W1999412042 countsByYear W19994120422012 @default.
• W1999412042 countsByYear W19994120422014 @default.
• W1999412042 countsByYear W19994120422016 @default.
• W1999412042 countsByYear W19994120422017 @default.
• W1999412042 countsByYear W19994120422018 @default.
• W1999412042 countsByYear W19994120422023 @default.
• W1999412042 crossrefType "journal-article" @default.
• W1999412042 hasAuthorship W1999412042A5005154709 @default.
• W1999412042 hasAuthorship W1999412042A5030344996 @default.
• W1999412042 hasAuthorship W1999412042A5084350482 @default.
• W1999412042 hasAuthorship W1999412042A5085034433 @default.
• W1999412042 hasBestOaLocation W19994120424 @default.
• W1999412042 hasConcept C104317684 @default.
• W1999412042 hasConcept C127561419 @default.
• W1999412042 hasConcept C132538176 @default.
• W1999412042 hasConcept C135903288 @default.
• W1999412042 hasConcept C142724271 @default.
• W1999412042 hasConcept C167734588 @default.
• W1999412042 hasConcept C169760540 @default.
• W1999412042 hasConcept C170493617 @default.
• W1999412042 hasConcept C17077164 @default.
• W1999412042 hasConcept C171056886 @default.
• W1999412042 hasConcept C2776805952 @default.
• W1999412042 hasConcept C2777025900 @default.
• W1999412042 hasConcept C2778334475 @default.
• W1999412042 hasConcept C2779530196 @default.
• W1999412042 hasConcept C2780775167 @default.
• W1999412042 hasConcept C2781156865 @default.
• W1999412042 hasConcept C34425596 @default.
• W1999412042 hasConcept C502942594 @default.
• W1999412042 hasConcept C529278444 @default.
• W1999412042 hasConcept C55493867 @default.
• W1999412042 hasConcept C71924100 @default.
• W1999412042 hasConcept C86803240 @default.

• next