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- W1999416710 abstract "Abstract High performance liquid chromatography (HPLC) was used to determine the antigenotoxic activity of Lactobacillus salivarius ( L. salivarius ) and was compared with the traditional SOS-chromotest assay. After co-incubation of L. salivarius FDB89 with 4-Nitroquinoline- N -oxide (4-NQO) (20 mg l −1 ) for 3 hours, SOS-chromotest assay was carried out to test the antigenotoxicity of L. salivarius FDB89. Simultaneously HPLC assay was used to determine the quantitative change of 4-NQO before and after co-incubation with L. salivarius FDB89. HPLC assay was performed on a reversed phase C18 column with UV detection at 365 nm and the flow rate was 1.0 ml min −1 . HPLC results clearly show that the toxic 4-NQO is converted to less toxic compounds and therefore its genotoxicity is inhibited. The genotoxicity measured by SOS-chromotest and HPLC methods were positively correlated, with a square correlation coefficient ( R 2 ) of 0.991. Under the above conditions, instrument detection limits were 1.2 ng. The recovery of 4-NQO was 85%–98% when the cell densities were in the range of 10 6 –10 9 cfu ml −1 . The results suggest that the HPLC method can be a useful alternative to SOS-chromotest assay in detecting the antigenotoxicity of lactobacillus, in being more sensitive and accurate than the latter." @default.
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- W1999416710 date "2008-06-01" @default.
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- W1999416710 title "Analysis of Antigenotoxicity of Lactobacillus Salivarius by High Performance Liquid Chromatography" @default.
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- W1999416710 doi "https://doi.org/10.1016/s1872-2040(08)60040-7" @default.
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