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- W1999423577 abstract "Administration of 3-methylcholanthrene (3MC) to rats greatly enhanced the aryl hydrocarbon hydroxylase (AHH) activity of liver nuclei. However, the binding in vitro of [3H]benzo[a]pyrene (BP) to DNA within the nuclei which occurred at the same time as hydroxylation of BP was much less enhanced. Thin layer chromatography of the metabolites of BP produced by these nuclei revealed the same metabolites in similar relative amounts as were produced by rat liver microsomes prepared from rats which had received 3MC. The binding to DNA was further analysed by hydrolysis of the DNA and fractionation on a Sephadex column. This analysis revealed that the binding to DNA in nuclei was very similar in nature to that which occurred when calf-thymus DNA was added to microsomes metabolising BP." @default.
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- W1999423577 date "1976-03-01" @default.
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- W1999423577 title "Comparison of the metabolism of benzo[a]pyrene and binding to DNA caused by rat liver nuclei and microsomes" @default.
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- W1999423577 doi "https://doi.org/10.1016/0009-2797(76)90043-0" @default.
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