FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999429145> ?p ?o ?g. }

• W1999429145 endingPage "1510" @default.
• W1999429145 startingPage "1500" @default.
• W1999429145 abstract "Glucocorticoids (GCs) have long been accepted as being catabolic in nature, liberating energy substrates during times of stress to supply the increased metabolic demand of the body. The effects of GCs on adipose tissue metabolism are conflicting, however, because patients with elevated GCs present with central adiposity. We performed an extensive literature review of the effects of GCs on adipose tissue metabolism. The contradictory effects of GCs on lipid metabolism occur through a number of different mechanisms, some of which are well defined and others remain to be elucidated. Firstly, through increases in caloric and dietary fat intake, along with increased hydrolysis of circulating triglycerides (chylomicrons, very low-density lipoproteins) by lipoprotein lipase activity, GCs increase the amount of fatty acids in circulation, which are then available for ectopic fat distribution (liver, muscle, and central adipocytes). Glucocorticoids also increase de novo lipid production in hepatocytes through increased expression of fatty acid synthase. There is some controversy as to whether these same mechanisms occur in adipocytes, thereby contributing to adipose hypertrophy. Glucocorticoids promote preadipocyte conversion to mature adipocytes, causing hyperplasia of the adipose tissue. Glucocorticoids also have acute antilipolytic effect on adipocytes, whereas their genomic actions facilitate increased lipolysis after about 48 hours of exposure. The acute and long-term effects of GCs on adipose tissue lipolysis remain unclear. Although considerable evidence supports the notion that GCs increase lipolysis through glucocorticoid-induced increases of lipase expression, they clearly have antilipolytic effects within these same tissues and cell line models." @default.
• W1999429145 created "2016-06-24" @default.
• W1999429145 creator A5010316880 @default.
• W1999429145 creator A5043048639 @default.
• W1999429145 creator A5075661431 @default.
• W1999429145 date "2011-11-01" @default.
• W1999429145 modified "2023-10-17" @default.
• W1999429145 title "The effects of glucocorticoids on adipose tissue lipid metabolism" @default.
• W1999429145 cites W11515472 @default.
• W1999429145 cites W1610053523 @default.
• W1999429145 cites W169031003 @default.
• W1999429145 cites W1802106554 @default.
• W1999429145 cites W1847935543 @default.
• W1999429145 cites W1966690259 @default.
• W1999429145 cites W1970259819 @default.
• W1999429145 cites W1977641071 @default.
• W1999429145 cites W1985097119 @default.
• W1999429145 cites W1986798119 @default.
• W1999429145 cites W1991448709 @default.
• W1999429145 cites W1991680271 @default.
• W1999429145 cites W1995827966 @default.
• W1999429145 cites W1995958310 @default.
• W1999429145 cites W1996744282 @default.
• W1999429145 cites W1998181809 @default.
• W1999429145 cites W1998803081 @default.
• W1999429145 cites W1998919487 @default.
• W1999429145 cites W2009790358 @default.
• W1999429145 cites W2009842219 @default.
• W1999429145 cites W2014593901 @default.
• W1999429145 cites W2020845948 @default.
• W1999429145 cites W2024714952 @default.
• W1999429145 cites W2025196819 @default.
• W1999429145 cites W2029031435 @default.
• W1999429145 cites W2047008569 @default.
• W1999429145 cites W2048240224 @default.
• W1999429145 cites W2049981234 @default.
• W1999429145 cites W2050249644 @default.
• W1999429145 cites W2050972898 @default.
• W1999429145 cites W2055013625 @default.
• W1999429145 cites W2055651091 @default.
• W1999429145 cites W2059309914 @default.
• W1999429145 cites W2063229200 @default.
• W1999429145 cites W2064398002 @default.
• W1999429145 cites W2067285807 @default.
• W1999429145 cites W2071588443 @default.
• W1999429145 cites W2077296426 @default.
• W1999429145 cites W2077991483 @default.
• W1999429145 cites W2078967419 @default.
• W1999429145 cites W2079938187 @default.
• W1999429145 cites W2089563426 @default.
• W1999429145 cites W2090993804 @default.
• W1999429145 cites W2093165805 @default.
• W1999429145 cites W2095853712 @default.
• W1999429145 cites W2098274706 @default.
• W1999429145 cites W2100183198 @default.
• W1999429145 cites W2101290962 @default.
• W1999429145 cites W2104336216 @default.
• W1999429145 cites W2106614373 @default.
• W1999429145 cites W2110212189 @default.
• W1999429145 cites W2115274616 @default.
• W1999429145 cites W2117268230 @default.
• W1999429145 cites W2128352893 @default.
• W1999429145 cites W2129008449 @default.
• W1999429145 cites W2129546749 @default.
• W1999429145 cites W2131256997 @default.
• W1999429145 cites W2146358096 @default.
• W1999429145 cites W2156518031 @default.
• W1999429145 cites W2164529172 @default.
• W1999429145 cites W2170638889 @default.
• W1999429145 cites W2185515430 @default.
• W1999429145 cites W2259451302 @default.
• W1999429145 cites W3112313529 @default.
• W1999429145 cites W4234202500 @default.
• W1999429145 cites W4234357566 @default.
• W1999429145 cites W4240587623 @default.
• W1999429145 cites W4242179516 @default.
• W1999429145 cites W4243034719 @default.
• W1999429145 cites W4245186971 @default.
• W1999429145 cites W4253910217 @default.
• W1999429145 cites W4254550975 @default.
• W1999429145 doi "https://doi.org/10.1016/j.metabol.2011.06.012" @default.
• W1999429145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21864867" @default.
• W1999429145 hasPublicationYear "2011" @default.
• W1999429145 type Work @default.
• W1999429145 sameAs 1999429145 @default.
• W1999429145 citedByCount "407" @default.
• W1999429145 countsByYear W19994291452012 @default.
• W1999429145 countsByYear W19994291452013 @default.
• W1999429145 countsByYear W19994291452014 @default.
• W1999429145 countsByYear W19994291452015 @default.
• W1999429145 countsByYear W19994291452016 @default.
• W1999429145 countsByYear W19994291452017 @default.
• W1999429145 countsByYear W19994291452018 @default.
• W1999429145 countsByYear W19994291452019 @default.
• W1999429145 countsByYear W19994291452020 @default.
• W1999429145 countsByYear W19994291452021 @default.
• W1999429145 countsByYear W19994291452022 @default.
• W1999429145 countsByYear W19994291452023 @default.

• next