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• W1999436384 abstract "<b>OBJECTIVE:</b> To establish the impact of cardiovascular risk and schooling over the rate of progression of dementia due to Alzheimer9s disease (AD). <b>BACKGROUND:</b> Low schooling and cardiovascular risk have been implied as causative factors for AD; it is unknown whether cardiovascular risk may impact the rate of progression of AD in populations with low average schooling. <b>DESIGN/METHODS:</b> Patients with late-onset AD according to National Institute on Aging – Alzheimer9s Association criteria were recruited at the Department of Neurology and Neurosurgery of the Federal University of São Paulo (UNIFESP), and assessed for gender, schooling, cerebrovascular risk factors, and time since dementia onset to reach Clinical Dementia Rating (CDR) scores >1.0, and Mini-Mental State Examination (MMSE) scores of 20 and 15. Linear regression was employed for statistical analysis, with the threshold of significance set at ρ<0.05. <b>RESULTS:</b> A total of 146 consecutive patients were included; 103 (70.55%) were female and 43 (29.45%) were male. Mean schooling was 4.14±3.65 years (range 0-15). Mean age of AD onset was 72.9±6.1 years-old. The average time to reach CDR>1.0 (n=118) was 4.2±2.6 years; for MMSE=20 (n=143) it was 3.6±2.7 years, and for MMSE=15 (n=91) it was 4.9±2.8 years. Mean Framingham scores were 14.8±1.2 for male patients (range 11-17) and 19.8±2.5 for female patients (range 13-25). Mean 10-year cardiovascular risk was 14.3%±7.2%, higher for males (19.8%±5.1%;range 8%-30%) than for females (12.1%±6.7%;range 2%-30%). Higher Framingham scores predicted a faster progression for MMSE=15 in males (ρ<0.001), but not in females (ρ>0.7). Higher education was significant to female patients for later reaching MMSE=20 (F-ratio=4.35;ρ=0.04) and MMSE=15 (F-ratio=4.99;ρ<0.03), but not to male patients. No scores were significant for faster or slower reaching CDR>1.0. <b>CONCLUSIONS:</b> Cardiovascular risk assessed by way of Framingham scores seems to be more important for AD progression in male patients. Schooling was protective for female patients, but not for males in this sample. Supported by: CAPES. <b>Disclosure:</b> Dr. Ferreira De Oliveira has received research support from Gerson Lehrman Group. Dr. Bertolucci has received personal compensation for activities with Novartis, Janssen, Eli Lilly & Company, and Pfizer Inc. Dr. Smith has nothing to disclose. Dr. Chen has nothing to disclose." @default.
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• W1999436384 date "2007-08-20" @default.
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• W1999436384 title "A JAPANESE ADULT FORM OF CPT II DEFICIENCY ASSOCIATED WITH A HOMOZYGOUS F383Y MUTATION" @default.
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• W1999436384 doi "https://doi.org/10.1212/01.wnl.0000267665.44477.85" @default.
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