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- W1999447673 abstract "Post-transcriptional control of cytokine gene expression is essential for rapid and transient response to stimuli and external stress. In health, post-transcriptional control is exerted by a number of trans-acting RNA-binding proteins and cis-acting sequence elements. These elements exist largely in the 3' untranslated region and comprise microRNA targets and notably AU-rich elements, and exert regulated mRNA decay and translation repression. Defects in this control can lead to increased and sustained production of pro-inflammatory mediators contributing to several chronic inflammatory disease and cancer states. This introduction to the Journal's special issue on the topic summarizes, in a non-comprehensive list, the types of RNA-binding protein and their target cytokines, and potential contributions to disease, and presents the highlights of the individual reviews." @default.
- W1999447673 created "2016-06-24" @default.
- W1999447673 creator A5064097084 @default.
- W1999447673 date "2014-04-01" @default.
- W1999447673 modified "2023-09-26" @default.
- W1999447673 title "Post-Transcriptional Control of Cytokine Gene Expression in Health and Disease" @default.
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- W1999447673 doi "https://doi.org/10.1089/jir.2013.0151" @default.
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