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- W1999451344 abstract "Cys-loop neurotransmitter-gated ion channels were a well-known superfamily of synaptic receptors. A small revolution occurred when Tasneem et al. identified prokaryotic members of the family that lacked both the eponymous cysteines and obviously the neuronal context of their eukaryotic relatives. A decade later, a new foray into the phylogeny and evolution of the family brings more surprises still, including related channels in various unicellular eukaryotes, as well as Cys-less members in a number of Metazoan species. This prompts a significant rewrite of the evolutionary history of the more aptly named “Pro-loop” channels, while leaving many more questions open." @default.
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- W1999451344 date "2015-01-01" @default.
- W1999451344 modified "2023-10-18" @default.
- W1999451344 title "Evolution of Pro-Loop Channels: A Fresh Look at the Former Cys-Loop Family" @default.
- W1999451344 doi "https://doi.org/10.1016/j.bpj.2014.11.2361" @default.
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