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- W1999461450 abstract "Zusammenfassung: Zur Prüfung von Antimykotika auf ihre Wirkung bei Infektionen von Mänsen mit Aspergillus fumigatus warden 103 Sporen in eine Niere pro Tier inokuliert. Nach einer zweitägigen Behandlungsperiode erfolgte am dritten Versuchstag die Bestimmung der Keimdichte in den infizierten Nieren. Als Kriterium der Wirksamkeit diente die Reduktion an CFU im Vergleich zu unbehandelten Kontrollen. In diesem Modell erwies sich Amphotericin B, BAY N 7133 sowie Itraconazol wirksam, 5-Fluorcytosm, Miconazol and Ketoconazol hatten in den untersuchten Dosierungen keinen Effekt. Summary: For the evaluation of the antifungal activity of test compounds on marine aspergillosis, one kidney per animal was inoculated with 103 spores. After a treatment period of two days the animals were killed three days p. i. to assess the fungal load in the infected kidneys. The efficacy was studied by the reduction of colony forming units in comparison with the untreated controls. In this model amphotericin B, BAY N 7133 and itraconazole proved to be active whereas the applied doses of 5-fluorocytosine, miconazole and ketoconazole showed no activity." @default.
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- W1999461450 date "2009-04-24" @default.
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- W1999461450 title "Experimentelle renale Infektionen der Maus mit Aspergillus fumigatus: Ein chemotherapeutisches Modell einer Organmykose: Experimental Renal Infection with Aspergillus fumigatus in Mice: A Chemotherapeutic Model of an Organic Mycosis" @default.
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- W1999461450 doi "https://doi.org/10.1111/j.1439-0507.1985.tb02124.x" @default.
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