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• W1999461895 endingPage "3405" @default.
• W1999461895 startingPage "3397" @default.
• W1999461895 abstract "Centrally expressed 5-HT3 receptors (5-HTR3) are well known for their role in wakefulness, cognition, and nociception. However, clear evidence of their participation in motor control is still lacking despite specific 5-HTR3 expression in hindlimb motor areas of the spinal cord (i.e., lumbar laminae VII-IX). Here, we studied the acute effects of 4-amino-(6-chloro-2-pyridyl)-1-piperidine hydrochloride (SR 57227A), a potent and selective 5-HTR3 agonist, on hindlimb movement generation in complete paraplegic mice. The induced movements were assessed in open-field, air-stepping, and treadmill conditions using a combination of qualitative and quantitative methods. The results revealed that SR 57227A (1-4 mg/kg ip) produced hindlimb movements corresponding to scores ranging from 1 to 5 on the motor scales of Basso, Beattie, and Bresnahan and of Antri, Orsal, and Barthe. Additional analyses revealed that one-third of the movements displayed on a treadmill were locomotor-like (i.e., bilateral alternation), whereas only nonlocomotor movements were observed in the other testing conditions suggesting a task-dependent contribution of peripheral afferent inputs to these effects. Locomotor-like movements could also be induced in open field and air stepping if SR 57227A was combined with subthreshold doses of 5-carboxytryptamine (5-HT1A/7 receptor agonist), suggesting synergistic actions of these drugs on central neurons. These results demonstrate that 5-HTR3 activation can induce motor activity and, under some conditions, rhythmic locomotor-like movements in the hindlimbs of paraplegic mice providing evidence of an unsuspected role for this receptor subtype in hindlimb motor control." @default.
• W1999461895 created "2016-06-24" @default.
• W1999461895 creator A5004651288 @default.
• W1999461895 creator A5078284276 @default.
• W1999461895 date "2005-11-01" @default.
• W1999461895 modified "2023-10-10" @default.
• W1999461895 title "Ionotropic 5-HT₃ Receptor Agonist-Induced Motor Responses in the Hindlimbs of Paraplegic Mice" @default.
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• W1999461895 doi "https://doi.org/10.1152/jn.00587.2005" @default.
• W1999461895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16049141" @default.
• W1999461895 hasPublicationYear "2005" @default.
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