FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999462527> ?p ?o ?g. }

• W1999462527 endingPage "2595" @default.
• W1999462527 startingPage "2590" @default.
• W1999462527 abstract ": To study the efficacy of intratracheal colistin sulfate therapy in a murine model of acute pneumonia caused by a clinical CRAB strain, Ab396. Colistin therapy has currently achieved a favorable outcome in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections, but parenteral colistin may have limited therapeutic efficacy for CRAB pneumonia.: A controlled, in vivo experimental study.: Research laboratory of a medical center.: Female BALB/c mice.: The minimal inhibitory concentrations of antibiotics were measured. Acute pneumonia was established by intratracheal inoculation with an inoculum size of 2.5 x 10 colony-forming units Ab396 plus 10% porcine mucin into the lungs of mice, verified by histopathological examinations, and then treated with or without antibiotics. Mice received intratracheal saline treatment as a control group, intraperitoneal administration (IP) imipenem/cilastatin plus sulbactam (IP IS group, 80/80 mg/kg and 40 mg/kg every 8 hrs, n = 30), IP colistin sulfate (IP CS group, 150,000 U/kg every 8 hrs, n = 30), and intratracheal colistin sulfate (intratracheal CS group, 75,000 U/kg every 8 hrs, n = 30) at 2 hrs after intratracheal inoculation of Ab396.: The minimal inhibitory concentrations of colistin sulfate, imipenem/cilastatin, or sulbactam for Ab396 were 2 microg/mL, 128 microg/mL, or 32 microg/mL, respectively. Compared with the mice in the control, IP IS, and IP CS groups, those in intratracheal CS group had a significantly favorable outcome at 72 hrs after infection (survival rate = 0%, 10%, 0% and 100%, respectively; all p < .001, log-rank test). Furthermore, intratracheal therapy decreased significantly the bacterial loads in the lungs and normalized the wet lung/body weight ratios in mice with acute pneumonia.: The intratracheal colistin sulfate therapy led to more favorable outcomes than therapies by IP colistin sulfate or imipenem/cilastatin plus sulbactam in mice with early CRAB pneumonia." @default.
• W1999462527 created "2016-06-24" @default.
• W1999462527 creator A5026090111 @default.
• W1999462527 creator A5029166845 @default.
• W1999462527 creator A5043815192 @default.
• W1999462527 creator A5044201260 @default.
• W1999462527 creator A5045767545 @default.
• W1999462527 creator A5046876682 @default.
• W1999462527 creator A5052795311 @default.
• W1999462527 creator A5090945062 @default.
• W1999462527 date "2009-09-01" @default.
• W1999462527 modified "2023-09-25" @default.
• W1999462527 title "Intratracheal colistin sulfate for BALB/c mice with early pneumonia caused by carbapenem-resistant Acinetobacter baumannii" @default.
• W1999462527 cites W1497505422 @default.
• W1999462527 cites W1588092333 @default.
• W1999462527 cites W1602597014 @default.
• W1999462527 cites W1748512628 @default.
• W1999462527 cites W1876584253 @default.
• W1999462527 cites W1978062981 @default.
• W1999462527 cites W1984899711 @default.
• W1999462527 cites W1993601543 @default.
• W1999462527 cites W2026681439 @default.
• W1999462527 cites W2031679173 @default.
• W1999462527 cites W2070131010 @default.
• W1999462527 cites W2091015559 @default.
• W1999462527 cites W2113717321 @default.
• W1999462527 cites W2117795567 @default.
• W1999462527 cites W2122995677 @default.
• W1999462527 cites W2123122657 @default.
• W1999462527 cites W2124996394 @default.
• W1999462527 cites W2130764129 @default.
• W1999462527 cites W2136291881 @default.
• W1999462527 cites W2145645537 @default.
• W1999462527 cites W2150188452 @default.
• W1999462527 cites W2161229311 @default.
• W1999462527 cites W2162441319 @default.
• W1999462527 cites W2163645360 @default.
• W1999462527 cites W2171214880 @default.
• W1999462527 cites W2917862595 @default.
• W1999462527 doi "https://doi.org/10.1097/ccm.0b013e3181a0f8e1" @default.
• W1999462527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19623044" @default.
• W1999462527 hasPublicationYear "2009" @default.
• W1999462527 type Work @default.
• W1999462527 sameAs 1999462527 @default.
• W1999462527 citedByCount "29" @default.
• W1999462527 countsByYear W19994625272012 @default.
• W1999462527 countsByYear W19994625272013 @default.
• W1999462527 countsByYear W19994625272014 @default.
• W1999462527 countsByYear W19994625272015 @default.
• W1999462527 countsByYear W19994625272016 @default.
• W1999462527 countsByYear W19994625272017 @default.
• W1999462527 countsByYear W19994625272018 @default.
• W1999462527 countsByYear W19994625272019 @default.
• W1999462527 countsByYear W19994625272021 @default.
• W1999462527 countsByYear W19994625272022 @default.
• W1999462527 countsByYear W19994625272023 @default.
• W1999462527 crossrefType "journal-article" @default.
• W1999462527 hasAuthorship W1999462527A5026090111 @default.
• W1999462527 hasAuthorship W1999462527A5029166845 @default.
• W1999462527 hasAuthorship W1999462527A5043815192 @default.
• W1999462527 hasAuthorship W1999462527A5044201260 @default.
• W1999462527 hasAuthorship W1999462527A5045767545 @default.
• W1999462527 hasAuthorship W1999462527A5046876682 @default.
• W1999462527 hasAuthorship W1999462527A5052795311 @default.
• W1999462527 hasAuthorship W1999462527A5090945062 @default.
• W1999462527 hasConcept C126322002 @default.
• W1999462527 hasConcept C2776315533 @default.
• W1999462527 hasConcept C2777437143 @default.
• W1999462527 hasConcept C2777637488 @default.
• W1999462527 hasConcept C2777914695 @default.
• W1999462527 hasConcept C2778478555 @default.
• W1999462527 hasConcept C2779259085 @default.
• W1999462527 hasConcept C2779631663 @default.
• W1999462527 hasConcept C501593827 @default.
• W1999462527 hasConcept C523546767 @default.
• W1999462527 hasConcept C54355233 @default.
• W1999462527 hasConcept C71924100 @default.
• W1999462527 hasConcept C86803240 @default.
• W1999462527 hasConcept C89423630 @default.
• W1999462527 hasConcept C94665300 @default.
• W1999462527 hasConcept C98274493 @default.
• W1999462527 hasConceptScore W1999462527C126322002 @default.
• W1999462527 hasConceptScore W1999462527C2776315533 @default.
• W1999462527 hasConceptScore W1999462527C2777437143 @default.
• W1999462527 hasConceptScore W1999462527C2777637488 @default.
• W1999462527 hasConceptScore W1999462527C2777914695 @default.
• W1999462527 hasConceptScore W1999462527C2778478555 @default.
• W1999462527 hasConceptScore W1999462527C2779259085 @default.
• W1999462527 hasConceptScore W1999462527C2779631663 @default.
• W1999462527 hasConceptScore W1999462527C501593827 @default.
• W1999462527 hasConceptScore W1999462527C523546767 @default.
• W1999462527 hasConceptScore W1999462527C54355233 @default.
• W1999462527 hasConceptScore W1999462527C71924100 @default.
• W1999462527 hasConceptScore W1999462527C86803240 @default.
• W1999462527 hasConceptScore W1999462527C89423630 @default.
• W1999462527 hasConceptScore W1999462527C94665300 @default.
• W1999462527 hasConceptScore W1999462527C98274493 @default.
• W1999462527 hasIssue "9" @default.

• next