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- W1999462672 abstract "The effect of the selective 5-hydroxytryptamine (5-HT)3 receptor agonist YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate) on gut motility of fed ferrets was investigated. YM-31636 (0.1 mg/kg p.o.) induced a giant migrating contraction (GMC)-like, high-amplitude, ungrouped colonic contraction although it did not change the basal colonic motility pattern. This GMC-like contraction was always accompanied by defecation. Both GMC-like contraction and defecation were inhibited with the selective 5-HT3 receptor antagonist ramosetron. YM-31636 affected gastric, duodenal and ileal motility pattern only slightly. These results suggest that 5-HT3 receptor agonists such as YM-31636 are useful in treating constipation since they facilitate GMC-like contractions and defecation without undesired changes in gut motility pattern." @default.
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- W1999462672 date "2002-08-01" @default.
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- W1999462672 title "The effect of the selective 5-HT3 receptor agonist on ferret gut motility" @default.
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- W1999462672 doi "https://doi.org/10.1016/s0024-3205(02)01841-6" @default.
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