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• W1999462948 abstract "In this study, a new and rapid UV spectrophotometric (UV) method and a reversed phase high performance liquid chromatographic (LC) method were developed for quantitative estimation of flurbiprofen, a non-selective, non-steroidal, anti-inflammatory drug (NSAID), in pure form and in pharmaceutical dosage form. The solvent system, wavelength of detection, chromatographic conditions were optimized in order to maximize the sensitivity of both the proposed methods. The linear regression equations obtained by least square regression method were Abs=7.5906×10−2 concentration (μg/ml) + (−) 4.6210×10−2 for the UV method, and peak area=1.2652×102 concentration (ng/ml) + 1.4830×103 for the LC method. The detection limit as per the error propagation theory was found to be 0.34 μg/ml for UV method and 15 ng/ml for LC method. The developed methods were successfully employed with high degree of precision and accuracy for the estimation of total drug content in two commercial ophthalmic drops of flurbiprofen. The results of analysis were treated statistically, as per USP 2000 and International Conference on Harmonization (ICH) guidelines for validation of analytical procedures, and by recovery studies. The results obtained from UV method were comparable with those obtained by using LC. It was concluded that both the developed methods are equally accurate, sensitive, precise, reproducible, robust and rugged and could be applied directly and easily to the pharmaceutical preparations of flurbiprofen. However, LC method is useful at very low level (ng/ml), whereas UV method is suitable at μg/ml level." @default.
• W1999462948 created "2016-06-24" @default.
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• W1999462948 date "2002-07-01" @default.
• W1999462948 modified "2023-09-23" @default.
• W1999462948 title "Determination of flurbiprofen in pharmaceutical formulations by UV spectrophotometry and liquid chromatography" @default.
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• W1999462948 doi "https://doi.org/10.1016/s0003-2670(02)00426-9" @default.
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