FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999463404> ?p ?o ?g. }

• W1999463404 endingPage "114" @default.
• W1999463404 startingPage "99" @default.
• W1999463404 abstract "Members of the genus <i>Aspergillus</i> are opportunistic pathogens for cold- and warm- blooded animals. They are associated with an impressive spectrum of diseases in humans, ranging from benign colonization of the lung to life-threatening diseases such as invasive aspergillosis or allergic bronchopulmonary aspergillosis (ABPA). <i>Aspergillus fumigatus</i> is the etiological agent identified in most of the <i>Aspergillus</i>-related human diseases and is therefore of particular clinical relevance. A major problem in the diagnosis of <i>A. fumigatus</i>-related complications arises from the lack of standardized fungal extracts. The allergenicity of commercial <i>A. fumigatus</i> extracts depends on many factors including the strain used, growth conditions, harvesting and extraction procedures hampering the development of diagnostic reagents suitable for the discrimination between <i>A. fumigatus</i>-related diseases. Molecular DNA/RNA technologies and biotechnological procedures allow cloning, characterization and production of large amounts of single, highly pure allergens. The development of phage surface display technologies for cloning cDNAs has speeded up the isolation of candidate cDNAs encoding allergens. Screening of an <i>A. fumigatus</i> cDNA library displayed on the surface of phage M13 allowed characterization and production of a panel of allergens identified as proteins with known biological function or as allergens without sequence homology to known proteins. They belong to two functional categories: secreted and cytoplasmic proteins. Secreted allergens are recognized by serum IgE of <i>A. fumigatus</i>-sensitized individuals with or without ABPA, whereas nonsecreted allergens are exclusively recognized by serum IgE of ABPA patients. The dissection of IgE-mediated immune responses to single <i>A. fumigatus</i> allergens allows a discrimination between ABPA and <i>A. fumigatus</i> sensitization with high specificity and sensitivity demonstrating the power of recombinant allergens for the differential diagnosis of <i>A. fumigatus</i>-related pulmonary complications." @default.
• W1999463404 created "2016-06-24" @default.
• W1999463404 creator A5029018809 @default.
• W1999463404 date "1998-01-01" @default.
• W1999463404 modified "2023-09-25" @default.
• W1999463404 title "Recombinant Aspergillus fumigatus Allergens: From the Nucleotide Sequences to Clinical Applications" @default.
• W1999463404 cites W1982020244 @default.
• W1999463404 cites W2000038809 @default.
• W1999463404 cites W2003113302 @default.
• W1999463404 cites W2007286794 @default.
• W1999463404 cites W2022708664 @default.
• W1999463404 cites W2056411842 @default.
• W1999463404 cites W2089652099 @default.
• W1999463404 cites W2114624600 @default.
• W1999463404 doi "https://doi.org/10.1159/000023889" @default.
• W1999463404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9482698" @default.
• W1999463404 hasPublicationYear "1998" @default.
• W1999463404 type Work @default.
• W1999463404 sameAs 1999463404 @default.
• W1999463404 citedByCount "177" @default.
• W1999463404 countsByYear W19994634042012 @default.
• W1999463404 countsByYear W19994634042013 @default.
• W1999463404 countsByYear W19994634042014 @default.
• W1999463404 countsByYear W19994634042015 @default.
• W1999463404 countsByYear W19994634042016 @default.
• W1999463404 countsByYear W19994634042017 @default.
• W1999463404 countsByYear W19994634042018 @default.
• W1999463404 countsByYear W19994634042019 @default.
• W1999463404 countsByYear W19994634042020 @default.
• W1999463404 countsByYear W19994634042022 @default.
• W1999463404 countsByYear W19994634042023 @default.
• W1999463404 crossrefType "journal-article" @default.
• W1999463404 hasAuthorship W1999463404A5029018809 @default.
• W1999463404 hasConcept C104317684 @default.
• W1999463404 hasConcept C141105273 @default.
• W1999463404 hasConcept C159654299 @default.
• W1999463404 hasConcept C203014093 @default.
• W1999463404 hasConcept C2776391196 @default.
• W1999463404 hasConcept C2778871687 @default.
• W1999463404 hasConcept C2779175654 @default.
• W1999463404 hasConcept C2779787849 @default.
• W1999463404 hasConcept C40767141 @default.
• W1999463404 hasConcept C54355233 @default.
• W1999463404 hasConcept C86803240 @default.
• W1999463404 hasConcept C89423630 @default.
• W1999463404 hasConceptScore W1999463404C104317684 @default.
• W1999463404 hasConceptScore W1999463404C141105273 @default.
• W1999463404 hasConceptScore W1999463404C159654299 @default.
• W1999463404 hasConceptScore W1999463404C203014093 @default.
• W1999463404 hasConceptScore W1999463404C2776391196 @default.
• W1999463404 hasConceptScore W1999463404C2778871687 @default.
• W1999463404 hasConceptScore W1999463404C2779175654 @default.
• W1999463404 hasConceptScore W1999463404C2779787849 @default.
• W1999463404 hasConceptScore W1999463404C40767141 @default.
• W1999463404 hasConceptScore W1999463404C54355233 @default.
• W1999463404 hasConceptScore W1999463404C86803240 @default.
• W1999463404 hasConceptScore W1999463404C89423630 @default.
• W1999463404 hasIssue "2" @default.
• W1999463404 hasLocation W19994634041 @default.
• W1999463404 hasLocation W19994634042 @default.
• W1999463404 hasOpenAccess W1999463404 @default.
• W1999463404 hasPrimaryLocation W19994634041 @default.
• W1999463404 hasRelatedWork W1692461723 @default.
• W1999463404 hasRelatedWork W2000206987 @default.
• W1999463404 hasRelatedWork W2019242982 @default.
• W1999463404 hasRelatedWork W2059497665 @default.
• W1999463404 hasRelatedWork W2075594763 @default.
• W1999463404 hasRelatedWork W2409466119 @default.
• W1999463404 hasRelatedWork W2412125414 @default.
• W1999463404 hasRelatedWork W25157611 @default.
• W1999463404 hasRelatedWork W2545044906 @default.
• W1999463404 hasRelatedWork W2064359291 @default.
• W1999463404 hasVolume "115" @default.
• W1999463404 isParatext "false" @default.
• W1999463404 isRetracted "false" @default.
• W1999463404 magId "1999463404" @default.
• W1999463404 workType "article" @default.