Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999465016> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1999465016 abstract "Background: Tamoxifen (TAM) is a selective estrogen receptor modulator employed in the treatment of breast cancer. It is a prodrug with a complex metabolic pathway involving several phase I and II metabolic enzymes. TAM is metabolized by cytochrome P450 (CYP) enzymes to N-desmethyltamoxifen (NDM), 4-hydroxytamoxifen (4OHT) and endoxifen (END) with 4OHT and END being the active metabolites of TAM. CYP2D6 and CYP3A4/5 comprises the major CYP isoforms mediating the metabolism of TAM although other CYP isoforms also play a role. Polymorphisms present in genes encoding these CYP enzymes may influence the metabolism and pharmacokinetics of TAM and its metabolites. Methods: A total of 116 Asian breast cancer patients were genotyped for CYP3A5∗3 polymorphism while 104 of these patients were genotyped for CYP2D6. Plasma levels of TAM and its 3 metabolites were obtained at steady state. The occurrence of hot flashes were monitored. Results: The allelic frequencies of CYP2D6∗10 and CYP3A5∗3 in the breast cancer patients were 0.52 and 0.71, respectively. The plasma END level (median; range) of patients with CYP2D6∗10/∗10 (8.85; 6.27-34.68) was significantly lower compared to patients with CYP2D6∗1/∗1 (19.55; 4.18-42.56; pCYP2D6∗1/∗10 (16.18; 9.48-33.24; pCYP2D6∗10 was 359.02 ng/ml (124.7–590.65) and was significantly higher compared to patients with CYP2D6∗1/∗1 (239.27; 40.82-584.26; p=0.012). No associations were observed between the pharmacokinetics of TAM and CYP3A5∗3. Hot flashes, a common side-effect of TAM, occurred at an overall frequency of 0.208 in the patient population. Patients homozygous for the ∗10/∗10 genotype had the highest frequency of hot flashes compared to wild-type subjects (P>0.05). Conclusion: This exploratory study identified CYP2D6∗10 to be an important predictor of TAM pharmacokinetics in Asian breast cancer patients. Other polymorphisms present in CYP2D6 or genes encoding other enzymes involved in metabolism of TAM may be useful in explaining inter-individual variation in TAM pharmacokinetics. Citation Information: Clin Cancer Res 2010;16(7 Suppl):A1" @default.
- W1999465016 created "2016-06-24" @default.
- W1999465016 creator A5006827772 @default.
- W1999465016 creator A5010714400 @default.
- W1999465016 creator A5018256494 @default.
- W1999465016 creator A5019107660 @default.
- W1999465016 creator A5025947047 @default.
- W1999465016 creator A5043319498 @default.
- W1999465016 creator A5060680187 @default.
- W1999465016 creator A5079496026 @default.
- W1999465016 date "2010-04-01" @default.
- W1999465016 modified "2023-09-25" @default.
- W1999465016 title "Abstract A1: Impact ofCYP2D6∗10andCYP3A5∗3polymorphisms on the pharmacokinetics of tamoxifen in Asian breast cancer patients" @default.
- W1999465016 doi "https://doi.org/10.1158/1078-0432.tcme10-a1" @default.
- W1999465016 hasPublicationYear "2010" @default.
- W1999465016 type Work @default.
- W1999465016 sameAs 1999465016 @default.
- W1999465016 citedByCount "0" @default.
- W1999465016 crossrefType "proceedings-article" @default.
- W1999465016 hasAuthorship W1999465016A5006827772 @default.
- W1999465016 hasAuthorship W1999465016A5010714400 @default.
- W1999465016 hasAuthorship W1999465016A5018256494 @default.
- W1999465016 hasAuthorship W1999465016A5019107660 @default.
- W1999465016 hasAuthorship W1999465016A5025947047 @default.
- W1999465016 hasAuthorship W1999465016A5043319498 @default.
- W1999465016 hasAuthorship W1999465016A5060680187 @default.
- W1999465016 hasAuthorship W1999465016A5079496026 @default.
- W1999465016 hasConcept C104317684 @default.
- W1999465016 hasConcept C108215921 @default.
- W1999465016 hasConcept C109650736 @default.
- W1999465016 hasConcept C112705442 @default.
- W1999465016 hasConcept C121608353 @default.
- W1999465016 hasConcept C126322002 @default.
- W1999465016 hasConcept C134018914 @default.
- W1999465016 hasConcept C135763542 @default.
- W1999465016 hasConcept C143998085 @default.
- W1999465016 hasConcept C2777176818 @default.
- W1999465016 hasConcept C33664856 @default.
- W1999465016 hasConcept C526171541 @default.
- W1999465016 hasConcept C530470458 @default.
- W1999465016 hasConcept C54355233 @default.
- W1999465016 hasConcept C62231903 @default.
- W1999465016 hasConcept C71924100 @default.
- W1999465016 hasConcept C86803240 @default.
- W1999465016 hasConcept C92137452 @default.
- W1999465016 hasConcept C98274493 @default.
- W1999465016 hasConceptScore W1999465016C104317684 @default.
- W1999465016 hasConceptScore W1999465016C108215921 @default.
- W1999465016 hasConceptScore W1999465016C109650736 @default.
- W1999465016 hasConceptScore W1999465016C112705442 @default.
- W1999465016 hasConceptScore W1999465016C121608353 @default.
- W1999465016 hasConceptScore W1999465016C126322002 @default.
- W1999465016 hasConceptScore W1999465016C134018914 @default.
- W1999465016 hasConceptScore W1999465016C135763542 @default.
- W1999465016 hasConceptScore W1999465016C143998085 @default.
- W1999465016 hasConceptScore W1999465016C2777176818 @default.
- W1999465016 hasConceptScore W1999465016C33664856 @default.
- W1999465016 hasConceptScore W1999465016C526171541 @default.
- W1999465016 hasConceptScore W1999465016C530470458 @default.
- W1999465016 hasConceptScore W1999465016C54355233 @default.
- W1999465016 hasConceptScore W1999465016C62231903 @default.
- W1999465016 hasConceptScore W1999465016C71924100 @default.
- W1999465016 hasConceptScore W1999465016C86803240 @default.
- W1999465016 hasConceptScore W1999465016C92137452 @default.
- W1999465016 hasConceptScore W1999465016C98274493 @default.
- W1999465016 hasLocation W19994650161 @default.
- W1999465016 hasOpenAccess W1999465016 @default.
- W1999465016 hasPrimaryLocation W19994650161 @default.
- W1999465016 hasRelatedWork W1508284217 @default.
- W1999465016 hasRelatedWork W1797160017 @default.
- W1999465016 hasRelatedWork W1925142268 @default.
- W1999465016 hasRelatedWork W2012156333 @default.
- W1999465016 hasRelatedWork W2022919834 @default.
- W1999465016 hasRelatedWork W2028221670 @default.
- W1999465016 hasRelatedWork W2067114783 @default.
- W1999465016 hasRelatedWork W2402080167 @default.
- W1999465016 hasRelatedWork W2573513868 @default.
- W1999465016 hasRelatedWork W2586573224 @default.
- W1999465016 hasRelatedWork W2590504519 @default.
- W1999465016 hasRelatedWork W2606958490 @default.
- W1999465016 hasRelatedWork W2746976327 @default.
- W1999465016 hasRelatedWork W2895853627 @default.
- W1999465016 hasRelatedWork W2972970991 @default.
- W1999465016 hasRelatedWork W3019065741 @default.
- W1999465016 hasRelatedWork W3108287772 @default.
- W1999465016 hasRelatedWork W3143847491 @default.
- W1999465016 hasRelatedWork W3158883720 @default.
- W1999465016 hasRelatedWork W3195886874 @default.
- W1999465016 isParatext "false" @default.
- W1999465016 isRetracted "false" @default.
- W1999465016 magId "1999465016" @default.
- W1999465016 workType "article" @default.