Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999477960> ?p ?o ?g. }
- W1999477960 endingPage "e1003518" @default.
- W1999477960 startingPage "e1003518" @default.
- W1999477960 abstract "Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1(-/-) neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1(-/-) mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1(-/-) MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly." @default.
- W1999477960 created "2016-06-24" @default.
- W1999477960 creator A5000012529 @default.
- W1999477960 creator A5012569525 @default.
- W1999477960 creator A5021758753 @default.
- W1999477960 creator A5024592647 @default.
- W1999477960 creator A5030118718 @default.
- W1999477960 creator A5032471364 @default.
- W1999477960 creator A5037162298 @default.
- W1999477960 creator A5047385837 @default.
- W1999477960 creator A5048087410 @default.
- W1999477960 creator A5061861094 @default.
- W1999477960 date "2013-06-06" @default.
- W1999477960 modified "2023-10-17" @default.
- W1999477960 title "Histone Acetyl Transferase 1 Is Essential for Mammalian Development, Genome Stability, and the Processing of Newly Synthesized Histones H3 and H4" @default.
- W1999477960 cites W158157254 @default.
- W1999477960 cites W1965975821 @default.
- W1999477960 cites W1966218941 @default.
- W1999477960 cites W1966792552 @default.
- W1999477960 cites W1969438143 @default.
- W1999477960 cites W1969543649 @default.
- W1999477960 cites W1973549360 @default.
- W1999477960 cites W1974784924 @default.
- W1999477960 cites W1975859486 @default.
- W1999477960 cites W1980005178 @default.
- W1999477960 cites W1981017846 @default.
- W1999477960 cites W1982966836 @default.
- W1999477960 cites W1987271093 @default.
- W1999477960 cites W1990103859 @default.
- W1999477960 cites W1990726449 @default.
- W1999477960 cites W1994672948 @default.
- W1999477960 cites W1999144991 @default.
- W1999477960 cites W2002191009 @default.
- W1999477960 cites W2007538089 @default.
- W1999477960 cites W2007577994 @default.
- W1999477960 cites W2007884336 @default.
- W1999477960 cites W2010817679 @default.
- W1999477960 cites W2012025493 @default.
- W1999477960 cites W2012593128 @default.
- W1999477960 cites W2015529578 @default.
- W1999477960 cites W2018366980 @default.
- W1999477960 cites W2018680078 @default.
- W1999477960 cites W2028684043 @default.
- W1999477960 cites W2028895755 @default.
- W1999477960 cites W2038728467 @default.
- W1999477960 cites W2040540665 @default.
- W1999477960 cites W2042749688 @default.
- W1999477960 cites W2043405065 @default.
- W1999477960 cites W2045627002 @default.
- W1999477960 cites W2049984581 @default.
- W1999477960 cites W2052389165 @default.
- W1999477960 cites W2066213591 @default.
- W1999477960 cites W2066332561 @default.
- W1999477960 cites W2067783987 @default.
- W1999477960 cites W2071955851 @default.
- W1999477960 cites W2073293518 @default.
- W1999477960 cites W2088468607 @default.
- W1999477960 cites W2088853419 @default.
- W1999477960 cites W2090061341 @default.
- W1999477960 cites W2090682802 @default.
- W1999477960 cites W2092929124 @default.
- W1999477960 cites W2101032714 @default.
- W1999477960 cites W2107308955 @default.
- W1999477960 cites W2114506570 @default.
- W1999477960 cites W2114874351 @default.
- W1999477960 cites W2116015519 @default.
- W1999477960 cites W2123848753 @default.
- W1999477960 cites W2125726199 @default.
- W1999477960 cites W2132232570 @default.
- W1999477960 cites W2138991271 @default.
- W1999477960 cites W2139204366 @default.
- W1999477960 cites W2145929363 @default.
- W1999477960 cites W2148429447 @default.
- W1999477960 cites W2154401697 @default.
- W1999477960 cites W2156134501 @default.
- W1999477960 cites W2156222068 @default.
- W1999477960 cites W2168146428 @default.
- W1999477960 cites W2171139592 @default.
- W1999477960 cites W2198639770 @default.
- W1999477960 cites W2408941539 @default.
- W1999477960 doi "https://doi.org/10.1371/journal.pgen.1003518" @default.
- W1999477960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3675013" @default.
- W1999477960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23754951" @default.
- W1999477960 hasPublicationYear "2013" @default.
- W1999477960 type Work @default.
- W1999477960 sameAs 1999477960 @default.
- W1999477960 citedByCount "84" @default.
- W1999477960 countsByYear W19994779602013 @default.
- W1999477960 countsByYear W19994779602014 @default.
- W1999477960 countsByYear W19994779602015 @default.
- W1999477960 countsByYear W19994779602016 @default.
- W1999477960 countsByYear W19994779602017 @default.
- W1999477960 countsByYear W19994779602018 @default.
- W1999477960 countsByYear W19994779602019 @default.
- W1999477960 countsByYear W19994779602020 @default.
- W1999477960 countsByYear W19994779602021 @default.
- W1999477960 countsByYear W19994779602022 @default.
- W1999477960 countsByYear W19994779602023 @default.