FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999479318> ?p ?o ?g. }

• W1999479318 endingPage "576" @default.
• W1999479318 startingPage "569" @default.
• W1999479318 abstract "Recent studies have identified synaptic proteins that undergo synapse-to-nucleus translocation in response to neuronal activity that modulate protein synthesis. One such translational regulatory protein of the postsynaptic density (PSD) is AIDA-1d, which binds to PSD-95 via its C-terminus. Activation of synaptic NMDA receptors induces the cleavage of AIDA-1d, and the N-terminus is then shuttled to nuclear Cajal bodies where it plays a role in regulating global protein synthesis. Chronic ethanol exposure has been shown to increase the synaptic clustering of NMDA receptors and PSD-95. Here, we tested the hypothesis that AIDA-1d regulates chronic ethanol-induced increases in synaptic NMDA receptor expression. As reported, we found that AIDA-1 was highly enriched in dendritic spines and co-localized with PSD-95. Acute NMDA treatment increased AIDA-1 colocalization with p80 coilin, a marker of Cajal bodies. Chronic treatment (4 day) of cultures with ethanol (25–100 mM) or with the NMDA receptor antagonist AP-V (50 μM) enhanced the clustering of AIDA-1 at synaptic sites. However, chronic ethanol treatment (50 mM) in the presence of the NMDA receptor agonist NMDA (2.5 μM) prevented this increase. Surprisingly, PSD-95 did not seem to play a role in the synaptic distribution of AIDA-1 as this distribution was not affected by declustering PSD-95 from synapses in response to inhibition of palmitoylation. We found that lentiviral knockdown of AIDA-1d did not affect protein expression levels of NMDA receptor subunits GluN1, GluN1 C2′, or GluN2B. The results of this study demonstrate that synaptic AIDA-1 expression is enhanced by chronic ethanol exposure that can be prevented by concurrent stimulation of NMDA receptors. In addition, we found that the association of AIDA-1 with PSD-95 is not required for its localization to the PSD. Moreover, we found that AIDA-1 does not regulate protein expression levels or alternative splicing of the GluN1 subunit of NMDA receptors." @default.
• W1999479318 created "2016-06-24" @default.
• W1999479318 creator A5003155578 @default.
• W1999479318 creator A5051589166 @default.
• W1999479318 creator A5066176863 @default.
• W1999479318 date "2012-09-01" @default.
• W1999479318 modified "2023-10-06" @default.
• W1999479318 title "Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons" @default.
• W1999479318 cites W1586418235 @default.
• W1999479318 cites W1597908762 @default.
• W1999479318 cites W1964888903 @default.
• W1999479318 cites W1974814280 @default.
• W1999479318 cites W1979331753 @default.
• W1999479318 cites W1979717828 @default.
• W1999479318 cites W1982138808 @default.
• W1999479318 cites W1983199685 @default.
• W1999479318 cites W1983807711 @default.
• W1999479318 cites W2009216216 @default.
• W1999479318 cites W2009485863 @default.
• W1999479318 cites W2010762066 @default.
• W1999479318 cites W2011293417 @default.
• W1999479318 cites W2018458016 @default.
• W1999479318 cites W2083260329 @default.
• W1999479318 cites W2102769057 @default.
• W1999479318 cites W2103442566 @default.
• W1999479318 cites W2106971401 @default.
• W1999479318 cites W2110915628 @default.
• W1999479318 cites W2114871465 @default.
• W1999479318 cites W2118107253 @default.
• W1999479318 cites W2140012877 @default.
• W1999479318 cites W2142475134 @default.
• W1999479318 cites W2146357663 @default.
• W1999479318 cites W2151791677 @default.
• W1999479318 cites W2155909540 @default.
• W1999479318 cites W2159075930 @default.
• W1999479318 doi "https://doi.org/10.1016/j.alcohol.2012.04.004" @default.
• W1999479318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3411901" @default.
• W1999479318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22703994" @default.
• W1999479318 hasPublicationYear "2012" @default.
• W1999479318 type Work @default.
• W1999479318 sameAs 1999479318 @default.
• W1999479318 citedByCount "6" @default.
• W1999479318 countsByYear W19994793182013 @default.
• W1999479318 countsByYear W19994793182014 @default.
• W1999479318 countsByYear W19994793182015 @default.
• W1999479318 countsByYear W19994793182019 @default.
• W1999479318 crossrefType "journal-article" @default.
• W1999479318 hasAuthorship W1999479318A5003155578 @default.
• W1999479318 hasAuthorship W1999479318A5051589166 @default.
• W1999479318 hasAuthorship W1999479318A5066176863 @default.
• W1999479318 hasBestOaLocation W19994793182 @default.
• W1999479318 hasConcept C127445978 @default.
• W1999479318 hasConcept C148762608 @default.
• W1999479318 hasConcept C160268369 @default.
• W1999479318 hasConcept C169760540 @default.
• W1999479318 hasConcept C170493617 @default.
• W1999479318 hasConcept C174884520 @default.
• W1999479318 hasConcept C185592680 @default.
• W1999479318 hasConcept C187541742 @default.
• W1999479318 hasConcept C197341189 @default.
• W1999479318 hasConcept C55493867 @default.
• W1999479318 hasConcept C61174792 @default.
• W1999479318 hasConcept C67018056 @default.
• W1999479318 hasConcept C86803240 @default.
• W1999479318 hasConcept C95444343 @default.
• W1999479318 hasConceptScore W1999479318C127445978 @default.
• W1999479318 hasConceptScore W1999479318C148762608 @default.
• W1999479318 hasConceptScore W1999479318C160268369 @default.
• W1999479318 hasConceptScore W1999479318C169760540 @default.
• W1999479318 hasConceptScore W1999479318C170493617 @default.
• W1999479318 hasConceptScore W1999479318C174884520 @default.
• W1999479318 hasConceptScore W1999479318C185592680 @default.
• W1999479318 hasConceptScore W1999479318C187541742 @default.
• W1999479318 hasConceptScore W1999479318C197341189 @default.
• W1999479318 hasConceptScore W1999479318C55493867 @default.
• W1999479318 hasConceptScore W1999479318C61174792 @default.
• W1999479318 hasConceptScore W1999479318C67018056 @default.
• W1999479318 hasConceptScore W1999479318C86803240 @default.
• W1999479318 hasConceptScore W1999479318C95444343 @default.
• W1999479318 hasIssue "6" @default.
• W1999479318 hasLocation W19994793181 @default.
• W1999479318 hasLocation W19994793182 @default.
• W1999479318 hasLocation W19994793183 @default.
• W1999479318 hasLocation W19994793184 @default.
• W1999479318 hasOpenAccess W1999479318 @default.
• W1999479318 hasPrimaryLocation W19994793181 @default.
• W1999479318 hasRelatedWork W1991729369 @default.
• W1999479318 hasRelatedWork W1995307208 @default.
• W1999479318 hasRelatedWork W1998751065 @default.
• W1999479318 hasRelatedWork W2007990412 @default.
• W1999479318 hasRelatedWork W2020166428 @default.
• W1999479318 hasRelatedWork W2162918865 @default.
• W1999479318 hasRelatedWork W2620258884 @default.
• W1999479318 hasRelatedWork W2913382999 @default.
• W1999479318 hasRelatedWork W4286624379 @default.
• W1999479318 hasRelatedWork W4286825973 @default.
• W1999479318 hasVolume "46" @default.
• W1999479318 isParatext "false" @default.

• next