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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999482021> ?p ?o ?g. }

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• W1999482021 abstract "The ability of D‐6‐deoxy‐ myo ‐inositol 1,4,5‐trisphosphate [6‐deoxy‐Ins(1,4,5)P 3 ], a synthetic analogue of the second messenger D‐ myo ‐inositol 1,4,5‐trisphosphate [Ins(1,4,5)P 3 ], to mobilise intracellular Ca 2+ stores in permeabilised SH‐SY5Y neuroblastoma cells was investigated. 6‐Deoxy‐Ins(1,4,5)P 3 was a full agonist (EC 30 = 6.4 μM), but was some 70‐fold less potent than Ins (1,4,5)P 3 (EC 30 = 0.09 μM), indicating that the 6‐hydroxyl group of Ins(1,4,5)P 3 is most important for receptor binding and stimulation of Ca 2+ release, but is not an essential structural feature. 6‐Deoxy‐Ins(1,4,5)P 3 was not a substrate for Ins (1,4,5)P 3 5‐Phosphatase, but inhibited both the hydrolysis of 5‐[ 22 P] + Ins (1,4,5)P 3 ( K 1 76 μM) and the phosphorylation of [ 3 H]Ins(1,4,5)P 3 (apparent K 1 5.7 μM) 6‐Deoxy‐Ins (1,4,5)P 3 mobilized Ca 2+ with different kinetics to Ins(1,4,5)P 3 , indicating that it is probably a substrate for Ins(1,4,5)P 3 3‐kinase." @default.
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• W1999482021 date "1991-01-28" @default.
• W1999482021 modified "2023-10-18" @default.
• W1999482021 title "Interaction of synthetic D‐6‐deoxy‐<i>myo</i>‐inositol 1,4,5‐trisphosphate with the Ca²⁺‐releasing D‐<i>myo</i>‐inositol 1,4,5‐trisphosphate receptor, and the metabolic enzymes 5‐phosphatase and 3‐kinase" @default.
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• W1999482021 doi "https://doi.org/10.1016/0014-5793(91)80128-p" @default.
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