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• W1999486912 abstract "The uses of highly selective PPARbeta/delta ligands and PPARbeta/delta knockout mice have shown a direct ability of PPARbeta/delta to regulate angiogenesis in vitro and in vivo in animal models. PPARbeta/delta ligands induce the proangiogenic growth factor VEGF in many cells and tissues, though its actions in the eye are not known. However, virtually, all tissue components of the eye express PPARbeta/delta. Both angiogenesis and in particular VEGF are not only critical for the development of the retina, but they are also a central component in many common pathologies of the eye, including diabetic retinopathy and age-related macular degeneration, the most common causes of blindness in the Western world. This review, therefore, will discuss the recent evidence of PPARbeta/delta-mediated angiogenesis and VEGF release in the context of ocular disorders." @default.
• W1999486912 created "2016-06-24" @default.
• W1999486912 creator A5085555886 @default.
• W1999486912 date "2008-01-01" @default.
• W1999486912 modified "2023-09-23" @default.
• W1999486912 title "A Role for PPAR in Ocular Angiogenesis" @default.
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• W1999486912 doi "https://doi.org/10.1155/2008/825970" @default.
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