FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999487060> ?p ?o ?g. }

• W1999487060 endingPage "1658" @default.
• W1999487060 startingPage "1647" @default.
• W1999487060 abstract "Dopamine and noradrenaline are both involved in modulation of superior cognitive functions that are mainly dependent on frontal cortex activity. Experimental evidence points to parallel variations in extracellular concentrations of catecholamines in the cerebral cortex, which leads us to hypothesize their corelease from noradrenergic neurons. This study aimed to verify this hypothesis, by means of cerebral microdialysis following destruction of dopaminergic innervation in rats. The unilateral injury of dopaminergic neurons, by 6-hydroxydopamine injection in the ventral tegmental area, dramatically reduced the immunoreactivity for dopamine transporter in the cerebral hemisphere ipsilateral to the lesion. Tissue dopamine content in the ipsilateral nucleus accumbens and medial prefrontal and parietal cortex was also profoundly decreased, whereas noradrenaline was only slightly affected. Despite the lower tissue content in the denervated side, the extracellular dopamine level was not changed in the cortex, although it was markedly decreased in the nucleus accumbens ipsilateral to the lesion. The effect of drugs selective for D(2)-dopaminergic (haloperidol) or alpha(2)-noradrenergic (RS 79948) receptors was verified. Haloperidol failed to modify extracellular dopamine in either cortex but increased it in the nucleus accumbens, such an increase being greatly reduced in the denervated side. On the other hand, RS 79948 increased extracellular dopamine and DOPAC in all areas tested, the increases being of the same degree in both intact and lesioned sides. The results strongly support the hypothesis that the majority of extracellular dopamine in the cortex, unlike that in the nucleus accumbens, originates from noradrenergic terminals." @default.
• W1999487060 created "2016-06-24" @default.
• W1999487060 creator A5021970002 @default.
• W1999487060 creator A5023348741 @default.
• W1999487060 creator A5024422484 @default.
• W1999487060 creator A5049312678 @default.
• W1999487060 creator A5056536189 @default.
• W1999487060 creator A5057088988 @default.
• W1999487060 creator A5082558832 @default.
• W1999487060 creator A5084160667 @default.
• W1999487060 creator A5085224229 @default.
• W1999487060 date "2008-01-01" @default.
• W1999487060 modified "2023-10-13" @default.
• W1999487060 title "6-Hydroxydopamine lesion in the ventral tegmental area fails to reduce extracellular dopamine in the cerebral cortex" @default.
• W1999487060 cites W1493305388 @default.
• W1999487060 cites W1494321187 @default.
• W1999487060 cites W1536743176 @default.
• W1999487060 cites W1545985345 @default.
• W1999487060 cites W1679288996 @default.
• W1999487060 cites W1824827932 @default.
• W1999487060 cites W1904778114 @default.
• W1999487060 cites W1943060734 @default.
• W1999487060 cites W1968721836 @default.
• W1999487060 cites W1972927648 @default.
• W1999487060 cites W1976229306 @default.
• W1999487060 cites W1993752163 @default.
• W1999487060 cites W2014352503 @default.
• W1999487060 cites W2019376105 @default.
• W1999487060 cites W2021602283 @default.
• W1999487060 cites W2025267158 @default.
• W1999487060 cites W2039641058 @default.
• W1999487060 cites W2044907318 @default.
• W1999487060 cites W2048207116 @default.
• W1999487060 cites W2051694556 @default.
• W1999487060 cites W2051804637 @default.
• W1999487060 cites W2052039259 @default.
• W1999487060 cites W2054231808 @default.
• W1999487060 cites W2059948898 @default.
• W1999487060 cites W2064028650 @default.
• W1999487060 cites W2082431448 @default.
• W1999487060 cites W2086151698 @default.
• W1999487060 cites W2092895227 @default.
• W1999487060 cites W2111281708 @default.
• W1999487060 cites W2120663831 @default.
• W1999487060 cites W2131341859 @default.
• W1999487060 cites W2145476174 @default.
• W1999487060 cites W2153323910 @default.
• W1999487060 cites W2158402972 @default.
• W1999487060 doi "https://doi.org/10.1002/jnr.21611" @default.
• W1999487060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18189323" @default.
• W1999487060 hasPublicationYear "2008" @default.
• W1999487060 type Work @default.
• W1999487060 sameAs 1999487060 @default.
• W1999487060 citedByCount "27" @default.
• W1999487060 countsByYear W19994870602012 @default.
• W1999487060 countsByYear W19994870602013 @default.
• W1999487060 countsByYear W19994870602014 @default.
• W1999487060 countsByYear W19994870602016 @default.
• W1999487060 countsByYear W19994870602017 @default.
• W1999487060 countsByYear W19994870602019 @default.
• W1999487060 countsByYear W19994870602020 @default.
• W1999487060 countsByYear W19994870602023 @default.
• W1999487060 crossrefType "journal-article" @default.
• W1999487060 hasAuthorship W1999487060A5021970002 @default.
• W1999487060 hasAuthorship W1999487060A5023348741 @default.
• W1999487060 hasAuthorship W1999487060A5024422484 @default.
• W1999487060 hasAuthorship W1999487060A5049312678 @default.
• W1999487060 hasAuthorship W1999487060A5056536189 @default.
• W1999487060 hasAuthorship W1999487060A5057088988 @default.
• W1999487060 hasAuthorship W1999487060A5082558832 @default.
• W1999487060 hasAuthorship W1999487060A5084160667 @default.
• W1999487060 hasAuthorship W1999487060A5085224229 @default.
• W1999487060 hasConcept C126322002 @default.
• W1999487060 hasConcept C134018914 @default.
• W1999487060 hasConcept C137183658 @default.
• W1999487060 hasConcept C169760540 @default.
• W1999487060 hasConcept C169900460 @default.
• W1999487060 hasConcept C185592680 @default.
• W1999487060 hasConcept C2776552330 @default.
• W1999487060 hasConcept C2780948874 @default.
• W1999487060 hasConcept C2781195155 @default.
• W1999487060 hasConcept C28406088 @default.
• W1999487060 hasConcept C513476851 @default.
• W1999487060 hasConcept C55493867 @default.
• W1999487060 hasConcept C71924100 @default.
• W1999487060 hasConcept C86803240 @default.
• W1999487060 hasConceptScore W1999487060C126322002 @default.
• W1999487060 hasConceptScore W1999487060C134018914 @default.
• W1999487060 hasConceptScore W1999487060C137183658 @default.
• W1999487060 hasConceptScore W1999487060C169760540 @default.
• W1999487060 hasConceptScore W1999487060C169900460 @default.
• W1999487060 hasConceptScore W1999487060C185592680 @default.
• W1999487060 hasConceptScore W1999487060C2776552330 @default.
• W1999487060 hasConceptScore W1999487060C2780948874 @default.
• W1999487060 hasConceptScore W1999487060C2781195155 @default.
• W1999487060 hasConceptScore W1999487060C28406088 @default.
• W1999487060 hasConceptScore W1999487060C513476851 @default.
• W1999487060 hasConceptScore W1999487060C55493867 @default.

• next