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• W1999492493 abstract "This study describes a strategy for the covalent immobilization of active adhesion peptide moieties onto polymers through the intermediacy of itaconic acid. The arginine–glycine–aspartic acid peptide was grafted to a novel poly(caprolactone 2-(methacryloyloxy) ethyl ester)- co-itaconic acid bulk biomaterial, in order to improve the cell adhesion of the polymer. First, the arginine–glycine–aspartic acid sequence was grafted onto itaconic acid via an amidation reaction using N-(3-dimethylaminopropyl)- N′-ethylcarbodiimide hydrochloride/ N-hydroxysuccinimide as activation complex. The itaconic acid–arginine–glycine–aspartic acid macromer was characterized by Fourier transform infrared spectroscopy and 1 H-NMR, yielding a functionalization degree of 85%. In a second step, poly(caprolactone 2-(methacryloyloxy) ethyl ester- co-itaconic acid–arginine–glycine–aspartic acid) (with a feed mixture of 90 wt% of caprolactone 2-(methacryloyloxy) ethyl ester and 10 wt% of itaconic acid–arginine–glycine–aspartic acid macromer) and a series of copolymers of caprolactone 2-(methacryloyloxy) ethyl ester and itaconic acid with different compositions (weight fractions of itaconic acid up to 20 wt%) were synthesized by radical copolymerization. The microstructure and network architecture of the new polymer systems were investigated. Mechanical moduli of poly(caprolactone 2-(methacryloyloxy) ethyl ester- co-itaconic acid), evaluated by dynamic–mechanical analysis, increase with the itaconic acid content. In poly(caprolactone 2-(methacryloyloxy) ethyl ester- co-itaconic acid–arginine–glycine–aspartic acid), the glass transition temperature and the mechanical moduli of the system are smaller than in the nonfunctionalized poly(caprolactone 2-(methacryloyloxy) ethyl ester- co-itaconic acid) copolymers, and the polymer is less hydrophilic. The results indicate that arginine–glycine–aspartic acid grafting of poly(caprolactone 2-(methacryloyloxy) ethyl ester- co-itaconic acid) copolymer networks can be useful for tissue engineering applications, because regenerative processes in the nervous system can be promoted and accelerated, thus, opening a possibility to generate materials with a high potential for clinical applicability." @default.
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• W1999492493 date "2013-01-01" @default.
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• W1999492493 title "Polymer chains incorporating caprolactone and arginine–glycine–aspartic acid functionalities: Synthesis, characterization and biological response in vitro of the Schwann cell" @default.
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• W1999492493 doi "https://doi.org/10.1177/0883911512469710" @default.
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