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- W1999493039 abstract "Abstract Thrombin stimulation of [32P]-prelabeled platelets induces a rapid decrease of the radioactivity from phosphatidylinositol-4,5-bisphosphate. No significant change is observed in phosphatidylinositol-4-monophosphate. The initial, thrombin-induced decrease of phosphatidylinositol-4,5-bisphosphate is not inhibited by cytochalasin D or by compounds that interfere with the mobilization of Ca2+ such as 8-(diethylamino)-octyl-3,4,5-trimethoxybenzoate, the calmodulin-antagonist, trifluoperazine, prostacyclin and cyclic AMP. Our information indicates that the rapid loss of phosphatidylinositol-4,5-bisphosphate is linked to receptor activation and insensitive to Ca2+-mobilization." @default.
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- W1999493039 date "1982-11-01" @default.
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- W1999493039 title "Degradation of phosphatidylinositol-4,5-bisphosphate is insensitive to Ca2+ mobilization in stimulated platelets" @default.
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- W1999493039 doi "https://doi.org/10.1016/0006-291x(82)91587-x" @default.
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