Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999494606> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1999494606 endingPage "208" @default.
- W1999494606 startingPage "204" @default.
- W1999494606 abstract "Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra (SN) were challenged with L-DOPA (25 mg/kg, i.p.). One hour later, during the peak of rotational behavior, the animals were killed and the striatum and the SN were dissected and assayed for dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) content. While L-DOPA treatment elevated DA levels in the lesioned striatum by only 10%, DA levels in the lesioned SN were completely restored to normal levels. DOPAC levels showed similar changes. In order to establish whether the large DA increase in the lesioned SN contributed to L-DOPA-induced contralateral circling, animals were implanted with chronic in-dwelling cannulas in the lesioned SN. Infusion of the DOPA decarboxylase inhibitor carbidopa (5 micrograms in 1 microliter) 30 min prior to peripheral L-DOPA injection not only reduced contralateral circling but reversed the direction of turning 20 min after the L-DOPA injection. The results are discussed in terms of dopaminergic regulation of the striatonigral pathway, their clinical relevance to Parkinson's disease and the suggestion that the SN is an important site for the action of L-DOPA." @default.
- W1999494606 created "2016-06-24" @default.
- W1999494606 creator A5051823738 @default.
- W1999494606 creator A5073597315 @default.
- W1999494606 date "1988-06-01" @default.
- W1999494606 modified "2023-09-30" @default.
- W1999494606 title "Evidence that the substantia nigra is a site of action for l-DOPA" @default.
- W1999494606 cites W1917378969 @default.
- W1999494606 cites W1976429984 @default.
- W1999494606 cites W1984767115 @default.
- W1999494606 cites W1986814051 @default.
- W1999494606 cites W1997989498 @default.
- W1999494606 cites W1998529563 @default.
- W1999494606 cites W2007196954 @default.
- W1999494606 cites W2013929683 @default.
- W1999494606 cites W2041287773 @default.
- W1999494606 cites W2058016655 @default.
- W1999494606 cites W2064152877 @default.
- W1999494606 cites W2073507502 @default.
- W1999494606 cites W2082139619 @default.
- W1999494606 cites W2082967796 @default.
- W1999494606 doi "https://doi.org/10.1016/0304-3940(88)90382-5" @default.
- W1999494606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3393296" @default.
- W1999494606 hasPublicationYear "1988" @default.
- W1999494606 type Work @default.
- W1999494606 sameAs 1999494606 @default.
- W1999494606 citedByCount "59" @default.
- W1999494606 countsByYear W19994946062013 @default.
- W1999494606 countsByYear W19994946062014 @default.
- W1999494606 countsByYear W19994946062016 @default.
- W1999494606 countsByYear W19994946062017 @default.
- W1999494606 countsByYear W19994946062019 @default.
- W1999494606 countsByYear W19994946062022 @default.
- W1999494606 countsByYear W19994946062023 @default.
- W1999494606 crossrefType "journal-article" @default.
- W1999494606 hasAuthorship W1999494606A5051823738 @default.
- W1999494606 hasAuthorship W1999494606A5073597315 @default.
- W1999494606 hasConcept C126322002 @default.
- W1999494606 hasConcept C134018914 @default.
- W1999494606 hasConcept C137183658 @default.
- W1999494606 hasConcept C185592680 @default.
- W1999494606 hasConcept C2776355744 @default.
- W1999494606 hasConcept C2776754145 @default.
- W1999494606 hasConcept C2777288102 @default.
- W1999494606 hasConcept C2778187257 @default.
- W1999494606 hasConcept C2779134260 @default.
- W1999494606 hasConcept C2779734285 @default.
- W1999494606 hasConcept C2780062018 @default.
- W1999494606 hasConcept C2780304432 @default.
- W1999494606 hasConcept C2780938664 @default.
- W1999494606 hasConcept C2908591018 @default.
- W1999494606 hasConcept C513476851 @default.
- W1999494606 hasConcept C529278444 @default.
- W1999494606 hasConcept C552161191 @default.
- W1999494606 hasConcept C58824617 @default.
- W1999494606 hasConcept C71924100 @default.
- W1999494606 hasConceptScore W1999494606C126322002 @default.
- W1999494606 hasConceptScore W1999494606C134018914 @default.
- W1999494606 hasConceptScore W1999494606C137183658 @default.
- W1999494606 hasConceptScore W1999494606C185592680 @default.
- W1999494606 hasConceptScore W1999494606C2776355744 @default.
- W1999494606 hasConceptScore W1999494606C2776754145 @default.
- W1999494606 hasConceptScore W1999494606C2777288102 @default.
- W1999494606 hasConceptScore W1999494606C2778187257 @default.
- W1999494606 hasConceptScore W1999494606C2779134260 @default.
- W1999494606 hasConceptScore W1999494606C2779734285 @default.
- W1999494606 hasConceptScore W1999494606C2780062018 @default.
- W1999494606 hasConceptScore W1999494606C2780304432 @default.
- W1999494606 hasConceptScore W1999494606C2780938664 @default.
- W1999494606 hasConceptScore W1999494606C2908591018 @default.
- W1999494606 hasConceptScore W1999494606C513476851 @default.
- W1999494606 hasConceptScore W1999494606C529278444 @default.
- W1999494606 hasConceptScore W1999494606C552161191 @default.
- W1999494606 hasConceptScore W1999494606C58824617 @default.
- W1999494606 hasConceptScore W1999494606C71924100 @default.
- W1999494606 hasIssue "2" @default.
- W1999494606 hasLocation W19994946061 @default.
- W1999494606 hasLocation W19994946062 @default.
- W1999494606 hasOpenAccess W1999494606 @default.
- W1999494606 hasPrimaryLocation W19994946061 @default.
- W1999494606 hasRelatedWork W1967674224 @default.
- W1999494606 hasRelatedWork W1982704513 @default.
- W1999494606 hasRelatedWork W1999494606 @default.
- W1999494606 hasRelatedWork W2012190527 @default.
- W1999494606 hasRelatedWork W2089829388 @default.
- W1999494606 hasRelatedWork W2160879584 @default.
- W1999494606 hasRelatedWork W2163736797 @default.
- W1999494606 hasRelatedWork W2339380681 @default.
- W1999494606 hasRelatedWork W2765815361 @default.
- W1999494606 hasRelatedWork W591489749 @default.
- W1999494606 hasVolume "89" @default.
- W1999494606 isParatext "false" @default.
- W1999494606 isRetracted "false" @default.
- W1999494606 magId "1999494606" @default.
- W1999494606 workType "article" @default.