FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999506688> ?p ?o ?g. }

• W1999506688 endingPage "116" @default.
• W1999506688 startingPage "109" @default.
• W1999506688 abstract "<b><i>Background: </i></b>Secretion of ADP and ATP is an essential prerequisite for platelet aggregation. Impaired nucleotide secretion can cause aggregation defects and increased bleeding risk. Quantitative determination of platelet nucleotide content and exocytosis is thus of importance for the characterization and diagnosis of bleeding phenotypes. For transgenic animal models with hemostatic defects analysis of potential secretion defects is as well imperative. <b><i>Methods: </i></b>Supernatants of washed platelets and platelet-rich plasma were analyzed by HPLC for ADP and ATP concentration. Calibration of the HPLC data was accomplished with an internal standard compensating for loss of analyte, detection sensitivity, and interference of the biomatrix. <b><i>Results: </i></b>HPLC analysis of nucleotide secretion was carried out with human and mouse platelets. Detection limits were determined for washed platelet and platelet-rich plasma samples. In the physiological concentration range linearity with respect to the peak area is maintained. <b><i>Conclusion: </i></b>The method combines reasonable sensitivity with robustness. The internal standard ensures reliable quantification of nucleotide concentrations even in presence of otherwise interfering substances. The low sample consumption renders possible the application to analysis of small samples like in mouse experiments." @default.
• W1999506688 created "2016-06-24" @default.
• W1999506688 creator A5038866397 @default.
• W1999506688 creator A5070564162 @default.
• W1999506688 creator A5071949659 @default.
• W1999506688 creator A5091646104 @default.
• W1999506688 date "2013-01-01" @default.
• W1999506688 modified "2023-09-25" @default.
• W1999506688 title "Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay" @default.
• W1999506688 cites W1489735188 @default.
• W1999506688 cites W1498243413 @default.
• W1999506688 cites W1499133114 @default.
• W1999506688 cites W1539257065 @default.
• W1999506688 cites W1582130281 @default.
• W1999506688 cites W1799921543 @default.
• W1999506688 cites W1964563096 @default.
• W1999506688 cites W1970844304 @default.
• W1999506688 cites W1979098366 @default.
• W1999506688 cites W1980471410 @default.
• W1999506688 cites W1989938745 @default.
• W1999506688 cites W1997582390 @default.
• W1999506688 cites W1998097763 @default.
• W1999506688 cites W2003003982 @default.
• W1999506688 cites W2019750186 @default.
• W1999506688 cites W2028876959 @default.
• W1999506688 cites W2037848555 @default.
• W1999506688 cites W2046058945 @default.
• W1999506688 cites W2054139090 @default.
• W1999506688 cites W2055801327 @default.
• W1999506688 cites W2062661650 @default.
• W1999506688 cites W2065940829 @default.
• W1999506688 cites W2069786094 @default.
• W1999506688 cites W2075612539 @default.
• W1999506688 cites W2077302198 @default.
• W1999506688 cites W2079859456 @default.
• W1999506688 cites W2080149769 @default.
• W1999506688 cites W2081093579 @default.
• W1999506688 cites W2091826825 @default.
• W1999506688 cites W2093248288 @default.
• W1999506688 cites W2096163228 @default.
• W1999506688 cites W2103490459 @default.
• W1999506688 cites W2105450378 @default.
• W1999506688 cites W2150641842 @default.
• W1999506688 cites W2210931878 @default.
• W1999506688 cites W2304879987 @default.
• W1999506688 cites W2343674894 @default.
• W1999506688 cites W2396080634 @default.
• W1999506688 cites W947480158 @default.
• W1999506688 doi "https://doi.org/10.1159/000350294" @default.
• W1999506688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3638993" @default.
• W1999506688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23652982" @default.
• W1999506688 hasPublicationYear "2013" @default.
• W1999506688 type Work @default.
• W1999506688 sameAs 1999506688 @default.
• W1999506688 citedByCount "24" @default.
• W1999506688 countsByYear W19995066882013 @default.
• W1999506688 countsByYear W19995066882014 @default.
• W1999506688 countsByYear W19995066882015 @default.
• W1999506688 countsByYear W19995066882016 @default.
• W1999506688 countsByYear W19995066882017 @default.
• W1999506688 countsByYear W19995066882018 @default.
• W1999506688 countsByYear W19995066882019 @default.
• W1999506688 countsByYear W19995066882020 @default.
• W1999506688 countsByYear W19995066882021 @default.
• W1999506688 countsByYear W19995066882022 @default.
• W1999506688 countsByYear W19995066882023 @default.
• W1999506688 crossrefType "journal-article" @default.
• W1999506688 hasAuthorship W1999506688A5038866397 @default.
• W1999506688 hasAuthorship W1999506688A5070564162 @default.
• W1999506688 hasAuthorship W1999506688A5071949659 @default.
• W1999506688 hasAuthorship W1999506688A5091646104 @default.
• W1999506688 hasBestOaLocation W19995066881 @default.
• W1999506688 hasConcept C104317684 @default.
• W1999506688 hasConcept C153911025 @default.
• W1999506688 hasConcept C179998833 @default.
• W1999506688 hasConcept C185592680 @default.
• W1999506688 hasConcept C203014093 @default.
• W1999506688 hasConcept C3018697912 @default.
• W1999506688 hasConcept C43617362 @default.
• W1999506688 hasConcept C49039625 @default.
• W1999506688 hasConcept C512185932 @default.
• W1999506688 hasConcept C55493867 @default.
• W1999506688 hasConcept C86803240 @default.
• W1999506688 hasConcept C89560881 @default.
• W1999506688 hasConceptScore W1999506688C104317684 @default.
• W1999506688 hasConceptScore W1999506688C153911025 @default.
• W1999506688 hasConceptScore W1999506688C179998833 @default.
• W1999506688 hasConceptScore W1999506688C185592680 @default.
• W1999506688 hasConceptScore W1999506688C203014093 @default.
• W1999506688 hasConceptScore W1999506688C3018697912 @default.
• W1999506688 hasConceptScore W1999506688C43617362 @default.
• W1999506688 hasConceptScore W1999506688C49039625 @default.
• W1999506688 hasConceptScore W1999506688C512185932 @default.
• W1999506688 hasConceptScore W1999506688C55493867 @default.
• W1999506688 hasConceptScore W1999506688C86803240 @default.
• W1999506688 hasConceptScore W1999506688C89560881 @default.
• W1999506688 hasIssue "2" @default.
• W1999506688 hasLocation W19995066881 @default.

• next