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- W1999506837 abstract "The in vivo metabolism of sulfatide was studied in the cerebellum and in the cerebrum of developing mice by intraperitoneal injection of [ 35 S]sulfate. After correction for the specific radioactivity of the sulfate, total sulfatide synthesis and degradation could be determined. The developmental patterns of synthesis and degradation of sulfatide in vivo were compared with the developmental activity patterns of the synthesizing enzyme cerebroside sulfotransferase (CST, EC 2.8.2.11), the degrading enzyme cerebroside sulfate sulfatase, measured as arylsulfatase A (ASA, EC 3.1.6.1), and the net sulfatide synthesis in both brain parts. During brain development, sulfatide synthesis per milligram of tissue was higher in the cerebellum than in the cerebrum. Its developmental pattern was similar but not identical to the CST activity in vitro . The in vivo pattern of sulfatide degradation followed that of sulfatide biosynthesis and was similar to the developmental activity pattern of ASA. During myelination 40–70% of the newly synthesized sulfatide was degraded within 24 hr, as measured in two ways: (1) by a 24-hr chase of the [ 25 S]sulfatide and (2) by calculating the difference between the total daily sulfatide synthesis and net daily accumulation of sulfatide. Both methods of determination gave similar results. The data presented show that the synthetic enzyme CST is fully active in vivo , producing more sulfatide than is necessary for incorporation into myelin. The resulting sulfatide excess is rapidly degraded in the lysosomes by the action of ASA. Thus net sulfatide synthesis is partly regulated by lysosomal degradation during myelination of the brain." @default.
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- W1999506837 title "Quantitative measurement of in vivo sulfatide metabolism during development of the mouse brain: Evidence for a large rapidly degradable sulfatide pool" @default.
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- W1999506837 doi "https://doi.org/10.1016/s0012-1606(81)80006-1" @default.
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