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- W1999517658 abstract "A number of endogenous mediators, including opioids, adenosine and bradykinin, which act on cardiac cell membrane receptors have been demonstrated to trigger the phenomenon termed ischemic preconditioning (IPC). IPC is an endogenous protective mechanism, whereby a brief period of ischemia or hypoxia protects a cell or organ, in this review the heart, against injury from a subsequent more prolonged stressful insult. Recent data suggest that opioid receptors are important triggers and/or mediators of this protective response. Selective pharmacological antagonists of the delta-or kappa-opioid receptor have been shown to block IPC, and agonists of these same receptors have been shown to mimic IPC in intact animals, isolated hearts or isolated cardiomyocytes. This review will summarize the current state of knowledge, which exists defining the role and cellular signaling pathways by which endogenously or exogenously administered opioids produce their cardioprotective response. The potential clinical application and evidence to suggest that opioids produce a similar protective effect in man will also be discussed." @default.
- W1999517658 created "2016-06-24" @default.
- W1999517658 creator A5030692703 @default.
- W1999517658 date "2003-07-01" @default.
- W1999517658 modified "2023-09-26" @default.
- W1999517658 title "Role of opioids in acute and delayed preconditioning" @default.
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- W1999517658 doi "https://doi.org/10.1016/s0022-2828(03)00135-4" @default.
- W1999517658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12818560" @default.
- W1999517658 hasPublicationYear "2003" @default.
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