Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999528036> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1999528036 endingPage "480" @default.
- W1999528036 startingPage "474" @default.
- W1999528036 abstract "Background: Guidelines for treatment of pediatric HIV have recently changed to recommend that all infants who are identified as HIV-infected should start antiretroviral treatment (ART) immediately, regardless of their immunologic or clinical status. This study aims to assess the likely impact of this change in guideline in South Africa. Methods: A mathematical model was developed to simulate mother-to-child transmission of HIV, disease progression, and death of HIV-infected children <15 years of age. The model is calibrated to South African data sources, including prevention of mother-to-child transmission program coverage data, pre-ART survival data, ART program statistics, and pediatric HIV prevalence studies. Results: Relative to what would be expected in the absence of early ART initiation, the number of infant AIDS deaths over the 2010–2025 period is expected to drop by 23.6% (95% confidence interval [CI]: 22.5–24.5%) at current levels of polymerase chain reaction (PCR) diagnosis, and by 34.2% (95% CI: 32.7–35.6%) if PCR diagnosis increases to 80% of perinatally infected infants at 2 months. However, the pediatric HIV disease burden has shifted toward older children in recent years. The effect of early ART on total pediatric AIDS mortality during the 2010–2025 period is therefore modest: a 9.8% reduction (95% CI: 7.9–12.6%) at current levels of PCR diagnosis, and a 14.2% reduction (95% CI: 11.4–18.2%) if PCR coverage increases to 80% of perinatally infected infants. Conclusion: The changes in ART guidelines for infants will have a significant impact on pediatric AIDS mortality at young ages, but further efforts are required to reduce the substantial growing AIDS mortality in older children." @default.
- W1999528036 created "2016-06-24" @default.
- W1999528036 creator A5014104423 @default.
- W1999528036 creator A5027479790 @default.
- W1999528036 creator A5033521226 @default.
- W1999528036 creator A5036851385 @default.
- W1999528036 creator A5050664360 @default.
- W1999528036 creator A5054286568 @default.
- W1999528036 creator A5062996779 @default.
- W1999528036 creator A5080603281 @default.
- W1999528036 date "2012-05-01" @default.
- W1999528036 modified "2023-10-03" @default.
- W1999528036 title "The Effect of Early Initiation of Antiretroviral Treatment in Infants on Pediatric AIDS Mortality in South Africa" @default.
- W1999528036 cites W2076333806 @default.
- W1999528036 doi "https://doi.org/10.1097/inf.0b013e3182456ba2" @default.
- W1999528036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22189531" @default.
- W1999528036 hasPublicationYear "2012" @default.
- W1999528036 type Work @default.
- W1999528036 sameAs 1999528036 @default.
- W1999528036 citedByCount "45" @default.
- W1999528036 countsByYear W19995280362012 @default.
- W1999528036 countsByYear W19995280362013 @default.
- W1999528036 countsByYear W19995280362014 @default.
- W1999528036 countsByYear W19995280362015 @default.
- W1999528036 countsByYear W19995280362016 @default.
- W1999528036 countsByYear W19995280362017 @default.
- W1999528036 countsByYear W19995280362018 @default.
- W1999528036 countsByYear W19995280362019 @default.
- W1999528036 countsByYear W19995280362020 @default.
- W1999528036 countsByYear W19995280362021 @default.
- W1999528036 countsByYear W19995280362022 @default.
- W1999528036 crossrefType "journal-article" @default.
- W1999528036 hasAuthorship W1999528036A5014104423 @default.
- W1999528036 hasAuthorship W1999528036A5027479790 @default.
- W1999528036 hasAuthorship W1999528036A5033521226 @default.
- W1999528036 hasAuthorship W1999528036A5036851385 @default.
- W1999528036 hasAuthorship W1999528036A5050664360 @default.
- W1999528036 hasAuthorship W1999528036A5054286568 @default.
- W1999528036 hasAuthorship W1999528036A5062996779 @default.
- W1999528036 hasAuthorship W1999528036A5080603281 @default.
- W1999528036 hasConcept C119599485 @default.
- W1999528036 hasConcept C126322002 @default.
- W1999528036 hasConcept C127413603 @default.
- W1999528036 hasConcept C142462285 @default.
- W1999528036 hasConcept C142724271 @default.
- W1999528036 hasConcept C187212893 @default.
- W1999528036 hasConcept C203014093 @default.
- W1999528036 hasConcept C2779134260 @default.
- W1999528036 hasConcept C2780182762 @default.
- W1999528036 hasConcept C2993143319 @default.
- W1999528036 hasConcept C3013748606 @default.
- W1999528036 hasConcept C44249647 @default.
- W1999528036 hasConcept C71924100 @default.
- W1999528036 hasConcept C761482 @default.
- W1999528036 hasConceptScore W1999528036C119599485 @default.
- W1999528036 hasConceptScore W1999528036C126322002 @default.
- W1999528036 hasConceptScore W1999528036C127413603 @default.
- W1999528036 hasConceptScore W1999528036C142462285 @default.
- W1999528036 hasConceptScore W1999528036C142724271 @default.
- W1999528036 hasConceptScore W1999528036C187212893 @default.
- W1999528036 hasConceptScore W1999528036C203014093 @default.
- W1999528036 hasConceptScore W1999528036C2779134260 @default.
- W1999528036 hasConceptScore W1999528036C2780182762 @default.
- W1999528036 hasConceptScore W1999528036C2993143319 @default.
- W1999528036 hasConceptScore W1999528036C3013748606 @default.
- W1999528036 hasConceptScore W1999528036C44249647 @default.
- W1999528036 hasConceptScore W1999528036C71924100 @default.
- W1999528036 hasConceptScore W1999528036C761482 @default.
- W1999528036 hasIssue "5" @default.
- W1999528036 hasLocation W19995280361 @default.
- W1999528036 hasLocation W19995280362 @default.
- W1999528036 hasOpenAccess W1999528036 @default.
- W1999528036 hasPrimaryLocation W19995280361 @default.
- W1999528036 hasRelatedWork W1973460911 @default.
- W1999528036 hasRelatedWork W1975146800 @default.
- W1999528036 hasRelatedWork W2055888974 @default.
- W1999528036 hasRelatedWork W2096903645 @default.
- W1999528036 hasRelatedWork W2115165681 @default.
- W1999528036 hasRelatedWork W2520411286 @default.
- W1999528036 hasRelatedWork W2911784407 @default.
- W1999528036 hasRelatedWork W4249487090 @default.
- W1999528036 hasRelatedWork W4322484426 @default.
- W1999528036 hasRelatedWork W2522518582 @default.
- W1999528036 hasVolume "31" @default.
- W1999528036 isParatext "false" @default.
- W1999528036 isRetracted "false" @default.
- W1999528036 magId "1999528036" @default.
- W1999528036 workType "article" @default.