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- W1999528046 abstract "Abstract: We found that γ-tocopherol, the predominant vitamin E form in diets, but not α-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. γ-Tocopherol induced apoptosis in androgen-sensitive LNCaP but not androgen-resistant PC-3 cells. Consequently, γ-tocopherol treatment caused cytochrome c release and caspase-9, -3 and -7 activation. However, the apoptosis could not be completely reversed by an irreversible pancaspase inhibitor, indicating that an alternative caspase-independent pathway may also be involved. Our study suggests that γ-tocopherol may be valuable in the prevention and therapy for certain types of cancer." @default.
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- W1999528046 date "2004-12-01" @default.
- W1999528046 modified "2023-09-24" @default.
- W1999528046 title "γ-Tocopherol Induces Apoptosis in Androgen-Responsive LNCaP Prostate Cancer Cells via Caspase-Dependent and Independent Mechanisms" @default.
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- W1999528046 doi "https://doi.org/10.1196/annals.1331.056" @default.
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