Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999541840> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1999541840 endingPage "927" @default.
- W1999541840 startingPage "919" @default.
- W1999541840 abstract "ABSTRACT Background: Agitation and aggression in Alzheimer's disease (AD) are amongst the most serious of neuropsychiatric symptoms, and contribute to poor outcomes and worse quality of life. Previous studies have suggested a benefit for memantine on agitation and aggression, but none have examined its efficacy in community-dwelling patients with significant agitation and aggression at baseline, utilizing these behaviors as a primary outcome measure. Methods: Patients with moderate-to-severe AD with Neuropsychiatric Inventory (NPI) total score ≥13 and NPI agitation/aggression score ≥1 were randomized to placebo or 20-mg memantine in a double-blind, 24-week trial. Co-primary outcome measures were behavior, measured by total NPI score, and cognition, using the Severe Impairment Battery (SIB). Secondary outcome measures included global assessment, function and other measures of behavior. This trial was registered as Clinicaltrials.gov: NCT00857649. Results: A total of 369 patients (average age = 75, average MMSE = 12) were randomized to placebo or memantine. The study was prematurely terminated due to recruitment problems. There were no statistically significant differences between memantine and placebo in mean change from baseline in NPI, SIB, or any of the secondary outcome measures. Behavior improved in both groups (total NPI change scores −3.90 ± 1.24 for memantine and −5.13 ± 1.23 for placebo). Memantine was generally well tolerated and patient retention in both treatment arms was good. Conclusions: The study failed to show the superiority of memantine in this sample of patients with moderate-to-severe AD with significant baseline agitation and aggression. Methodological limitations could have contributed to these results." @default.
- W1999541840 created "2016-06-24" @default.
- W1999541840 creator A5004968642 @default.
- W1999541840 creator A5011041823 @default.
- W1999541840 creator A5075980189 @default.
- W1999541840 creator A5076741931 @default.
- W1999541840 date "2013-03-08" @default.
- W1999541840 modified "2023-10-16" @default.
- W1999541840 title "A randomized, double-blind, placebo-controlled trial of memantine in a behaviorally enriched sample of patients with moderate-to-severe Alzheimer's disease" @default.
- W1999541840 cites W1164896577 @default.
- W1999541840 cites W144900321 @default.
- W1999541840 cites W1847168837 @default.
- W1999541840 cites W1985048555 @default.
- W1999541840 cites W1991168471 @default.
- W1999541840 cites W1996776294 @default.
- W1999541840 cites W2038074592 @default.
- W1999541840 cites W2045923955 @default.
- W1999541840 cites W2049132525 @default.
- W1999541840 cites W2062825859 @default.
- W1999541840 cites W2065741910 @default.
- W1999541840 cites W2099656611 @default.
- W1999541840 cites W2111963393 @default.
- W1999541840 cites W2113976466 @default.
- W1999541840 cites W2118470188 @default.
- W1999541840 cites W2132806643 @default.
- W1999541840 cites W2136332296 @default.
- W1999541840 cites W2139046272 @default.
- W1999541840 cites W2151585937 @default.
- W1999541840 cites W2152390559 @default.
- W1999541840 cites W2154596951 @default.
- W1999541840 cites W2156220037 @default.
- W1999541840 cites W2205815414 @default.
- W1999541840 doi "https://doi.org/10.1017/s1041610213000239" @default.
- W1999541840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23472619" @default.
- W1999541840 hasPublicationYear "2013" @default.
- W1999541840 type Work @default.
- W1999541840 sameAs 1999541840 @default.
- W1999541840 citedByCount "47" @default.
- W1999541840 countsByYear W19995418402014 @default.
- W1999541840 countsByYear W19995418402015 @default.
- W1999541840 countsByYear W19995418402016 @default.
- W1999541840 countsByYear W19995418402017 @default.
- W1999541840 countsByYear W19995418402018 @default.
- W1999541840 countsByYear W19995418402019 @default.
- W1999541840 countsByYear W19995418402020 @default.
- W1999541840 countsByYear W19995418402021 @default.
- W1999541840 countsByYear W19995418402022 @default.
- W1999541840 countsByYear W19995418402023 @default.
- W1999541840 crossrefType "journal-article" @default.
- W1999541840 hasAuthorship W1999541840A5004968642 @default.
- W1999541840 hasAuthorship W1999541840A5011041823 @default.
- W1999541840 hasAuthorship W1999541840A5075980189 @default.
- W1999541840 hasAuthorship W1999541840A5076741931 @default.
- W1999541840 hasConcept C118552586 @default.
- W1999541840 hasConcept C126322002 @default.
- W1999541840 hasConcept C142724271 @default.
- W1999541840 hasConcept C15744967 @default.
- W1999541840 hasConcept C168563851 @default.
- W1999541840 hasConcept C204787440 @default.
- W1999541840 hasConcept C27081682 @default.
- W1999541840 hasConcept C2779134260 @default.
- W1999541840 hasConcept C2779448149 @default.
- W1999541840 hasConcept C2779483572 @default.
- W1999541840 hasConcept C2779484449 @default.
- W1999541840 hasConcept C71924100 @default.
- W1999541840 hasConceptScore W1999541840C118552586 @default.
- W1999541840 hasConceptScore W1999541840C126322002 @default.
- W1999541840 hasConceptScore W1999541840C142724271 @default.
- W1999541840 hasConceptScore W1999541840C15744967 @default.
- W1999541840 hasConceptScore W1999541840C168563851 @default.
- W1999541840 hasConceptScore W1999541840C204787440 @default.
- W1999541840 hasConceptScore W1999541840C27081682 @default.
- W1999541840 hasConceptScore W1999541840C2779134260 @default.
- W1999541840 hasConceptScore W1999541840C2779448149 @default.
- W1999541840 hasConceptScore W1999541840C2779483572 @default.
- W1999541840 hasConceptScore W1999541840C2779484449 @default.
- W1999541840 hasConceptScore W1999541840C71924100 @default.
- W1999541840 hasIssue "6" @default.
- W1999541840 hasLocation W19995418401 @default.
- W1999541840 hasLocation W19995418402 @default.
- W1999541840 hasOpenAccess W1999541840 @default.
- W1999541840 hasPrimaryLocation W19995418401 @default.
- W1999541840 hasRelatedWork W2003306914 @default.
- W1999541840 hasRelatedWork W2015914873 @default.
- W1999541840 hasRelatedWork W2147654688 @default.
- W1999541840 hasRelatedWork W2370835924 @default.
- W1999541840 hasRelatedWork W2584342163 @default.
- W1999541840 hasRelatedWork W3049077005 @default.
- W1999541840 hasRelatedWork W3152037741 @default.
- W1999541840 hasRelatedWork W4224111004 @default.
- W1999541840 hasRelatedWork W4367309877 @default.
- W1999541840 hasRelatedWork W4379794305 @default.
- W1999541840 hasVolume "25" @default.
- W1999541840 isParatext "false" @default.
- W1999541840 isRetracted "false" @default.
- W1999541840 magId "1999541840" @default.
- W1999541840 workType "article" @default.