FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999557002> ?p ?o ?g. }

• W1999557002 endingPage "121" @default.
• W1999557002 startingPage "110" @default.
• W1999557002 abstract "Conjugated linoleic acid (CLA), a naturally occurring substance in food sources, occurs as mixtures of positional and geometrical isomers of octadecadienoate (18:2), and may inhibit colon tumorigenesis. It has been hypothesized that CLA can modulate cell proliferation and differentiation through the activation of peroxisome proliferator-activated receptors (PPARs), among which PPARγ is involved in growth inhibition of transformed cells. The aim of the present study was to investigate whether the antiproliferative effects of CLA are mediated by its interaction with PPARγ and APC/β-catenin signalling pathway in human colon cancer cells. In CLA-treated caco-2 cells we found a remarkable increase in the expression of PPARγ, which translocated into the nucleus, while PPARα and β/δ protein levels were not affected. GW259662, a well known PPARγ antagonist, blocked the increase in PPARγ protein rate and abrogated some biological effects of CLA, as it restored the proliferative capability of the cells and ERK1/2 phosphorylation level. We demonstrated that CLA treatment determined the down-regulation of APC and c-myc proteins, but in this case the administration of the antagonist was not able to revert CLA effects. Furthermore, CLA induced a reorganization of E-cadherin and β-catenin, as well as a redistribution of actin and tubulin filaments. Our data suggest that CLA may regulate PPARγ expression by selectively acting as an agonist; however, the discrepancies in PPARγ antagonist efficacy suggest the involvement of other pathways, independent of PPARγ, in CLA antiproliferative activity." @default.
• W1999557002 created "2016-06-24" @default.
• W1999557002 creator A5027182053 @default.
• W1999557002 creator A5040501332 @default.
• W1999557002 creator A5050608798 @default.
• W1999557002 creator A5065678199 @default.
• W1999557002 date "2007-08-01" @default.
• W1999557002 modified "2023-09-25" @default.
• W1999557002 title "Antiproliferative effect of conjugated linoleic acid in caco-2 cells: Involvement of PPARγ and APC/β-catenin pathways" @default.
• W1999557002 cites W1595610987 @default.
• W1999557002 cites W1780771399 @default.
• W1999557002 cites W1836452880 @default.
• W1999557002 cites W1877472591 @default.
• W1999557002 cites W1964694178 @default.
• W1999557002 cites W1971370742 @default.
• W1999557002 cites W1976222601 @default.
• W1999557002 cites W1978159411 @default.
• W1999557002 cites W1979201752 @default.
• W1999557002 cites W1980398250 @default.
• W1999557002 cites W1986398106 @default.
• W1999557002 cites W1991702726 @default.
• W1999557002 cites W1996982933 @default.
• W1999557002 cites W2001859337 @default.
• W1999557002 cites W2002897207 @default.
• W1999557002 cites W2004096576 @default.
• W1999557002 cites W2006718453 @default.
• W1999557002 cites W2018884883 @default.
• W1999557002 cites W2021796556 @default.
• W1999557002 cites W2026102591 @default.
• W1999557002 cites W2027838563 @default.
• W1999557002 cites W2029181833 @default.
• W1999557002 cites W2059479765 @default.
• W1999557002 cites W2064974844 @default.
• W1999557002 cites W2066585902 @default.
• W1999557002 cites W2071418980 @default.
• W1999557002 cites W2083059943 @default.
• W1999557002 cites W2090553336 @default.
• W1999557002 cites W2091321756 @default.
• W1999557002 cites W2092040814 @default.
• W1999557002 cites W2099939845 @default.
• W1999557002 cites W2100641407 @default.
• W1999557002 cites W2101304778 @default.
• W1999557002 cites W2105015609 @default.
• W1999557002 cites W2105140628 @default.
• W1999557002 cites W2111699218 @default.
• W1999557002 cites W2131408519 @default.
• W1999557002 cites W2135778926 @default.
• W1999557002 cites W2138602228 @default.
• W1999557002 cites W2140738689 @default.
• W1999557002 cites W2141662760 @default.
• W1999557002 cites W2148294117 @default.
• W1999557002 cites W2149520325 @default.
• W1999557002 cites W2152316752 @default.
• W1999557002 cites W2157445760 @default.
• W1999557002 cites W2159171218 @default.
• W1999557002 cites W2165011473 @default.
• W1999557002 cites W2168144075 @default.
• W1999557002 cites W2170807474 @default.
• W1999557002 cites W2171336112 @default.
• W1999557002 cites W2172765426 @default.
• W1999557002 cites W2336806886 @default.
• W1999557002 cites W4233070887 @default.
• W1999557002 doi "https://doi.org/10.1016/j.cbi.2007.05.010" @default.
• W1999557002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17632092" @default.
• W1999557002 hasPublicationYear "2007" @default.
• W1999557002 type Work @default.
• W1999557002 sameAs 1999557002 @default.
• W1999557002 citedByCount "23" @default.
• W1999557002 countsByYear W19995570022012 @default.
• W1999557002 countsByYear W19995570022013 @default.
• W1999557002 countsByYear W19995570022014 @default.
• W1999557002 countsByYear W19995570022015 @default.
• W1999557002 countsByYear W19995570022016 @default.
• W1999557002 countsByYear W19995570022017 @default.
• W1999557002 countsByYear W19995570022018 @default.
• W1999557002 countsByYear W19995570022019 @default.
• W1999557002 crossrefType "journal-article" @default.
• W1999557002 hasAuthorship W1999557002A5027182053 @default.
• W1999557002 hasAuthorship W1999557002A5040501332 @default.
• W1999557002 hasAuthorship W1999557002A5050608798 @default.
• W1999557002 hasAuthorship W1999557002A5065678199 @default.
• W1999557002 hasConcept C127078168 @default.
• W1999557002 hasConcept C134018914 @default.
• W1999557002 hasConcept C137620995 @default.
• W1999557002 hasConcept C170493617 @default.
• W1999557002 hasConcept C185592680 @default.
• W1999557002 hasConcept C187345961 @default.
• W1999557002 hasConcept C2776885963 @default.
• W1999557002 hasConcept C2779780233 @default.
• W1999557002 hasConcept C2780809830 @default.
• W1999557002 hasConcept C30145163 @default.
• W1999557002 hasConcept C543025807 @default.
• W1999557002 hasConcept C55493867 @default.
• W1999557002 hasConcept C62112901 @default.
• W1999557002 hasConcept C62478195 @default.
• W1999557002 hasConcept C86803240 @default.
• W1999557002 hasConcept C95444343 @default.
• W1999557002 hasConceptScore W1999557002C127078168 @default.

• next