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• W1999558502 endingPage "1417" @default.
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• W1999558502 abstract "OBJECTIVE: Increasing evidence implicates endothelin (ET)-1 in the pathophysiological development of cerebral vasospasm. This study examined the ability of TBC 11251 (TBC), a new ETA receptor antagonist, to prevent vasospasm in a rabbit model of subarachnoid hemorrhage (SAH). METHODS: Eighty-five New Zealand White rabbits were assigned to 1 of 10 groups. SAH was induced by injecting autologous blood into the cisterna magna. The treatment groups were as follows: 1) control (no SAH), 2) SAH alone, 3) SAH plus vehicle every 12 hours (BID), 4) SAH plus 5 mg/kg TBC BID, 5) SAH plus 10 mg/kg TBC BID, 6) SAH plus 20 mg/kg TBC BID, 7) SAH plus vehicle at 24 and 36 hours after SAH (24/36), 8) SAH plus 5 mg/kg TBC 24/36, 9) SAH plus 10 mg/kg TBC 24/36, and 10) SAH plus 20 mg/kg TBC 24/36. Animals were killed 48 hours after SAH, by perfusion-fixation, and then basilar arteries were histologically prepared and their cross-sectional areas were measured. RESULTS: The mean basilar artery cross-sectional area was constricted from 0.332 mm2 in the control group to 0.131 mm2 in the SAH alone group, 0.132 in the vehicle 24/36 group, and 0.125 in the vehicle BID group. All groups treated with TBC showed an increase in cross-sectional luminal basilar artery area, relative to the vehicle-treated groups. The 5 mg/kg TBC BID group exhibited a mean basilar artery area of 0.217 mm2, and the 10 mg/kg TBC BID group showed a mean basilar artery area of 0.240 mm2; both groups were statistically improved, compared with the vehicle-treated groups (P < 0.05). No side effects were seen, and there were no differences in the mean arterial pressures between drug- and vehicle-treated groups. CONCLUSION: These findings demonstrate that systemic administration of the ETA receptor antagonist TBC significantly attenuates cerebral vasospasm after SAH, thus providing additional support for the role of ET-1 in vasospasm." @default.
• W1999558502 created "2016-06-24" @default.
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• W1999558502 date "1998-12-01" @default.
• W1999558502 modified "2023-10-18" @default.
• W1999558502 title "Systemic Administration of the Endothelin- A Receptor Antagonist TBC 11251 At tenuates Cerebral Vasospasmafter Experimental Subarachnoid Hemorrhage: Dose Study and Review of End othelin-based Therapies in the Literatureon Cerebral Vasospasm" @default.
• W1999558502 cites W118738886 @default.
• W1999558502 cites W1542205514 @default.
• W1999558502 cites W1965065761 @default.
• W1999558502 cites W1965193922 @default.
• W1999558502 cites W1968157411 @default.
• W1999558502 cites W1971272271 @default.
• W1999558502 cites W1971997424 @default.
• W1999558502 cites W1973758743 @default.
• W1999558502 cites W1976046184 @default.
• W1999558502 cites W1979896022 @default.
• W1999558502 cites W1980762198 @default.
• W1999558502 cites W1980953062 @default.
• W1999558502 cites W1981446958 @default.
• W1999558502 cites W1984156130 @default.
• W1999558502 cites W1985369972 @default.
• W1999558502 cites W1986402230 @default.
• W1999558502 cites W1987359312 @default.
• W1999558502 cites W1988808856 @default.
• W1999558502 cites W1991352933 @default.
• W1999558502 cites W1993192780 @default.
• W1999558502 cites W1996179195 @default.
• W1999558502 cites W1998056753 @default.
• W1999558502 cites W2004455838 @default.
• W1999558502 cites W2005021150 @default.
• W1999558502 cites W2008914075 @default.
• W1999558502 cites W2011013688 @default.
• W1999558502 cites W2014172568 @default.
• W1999558502 cites W2014974012 @default.
• W1999558502 cites W2016664852 @default.
• W1999558502 cites W2017123940 @default.
• W1999558502 cites W2020234907 @default.
• W1999558502 cites W2022630683 @default.
• W1999558502 cites W2024322045 @default.
• W1999558502 cites W2026926934 @default.
• W1999558502 cites W2032419114 @default.
• W1999558502 cites W2034290120 @default.
• W1999558502 cites W2041123157 @default.
• W1999558502 cites W2047919022 @default.
• W1999558502 cites W2048553697 @default.
• W1999558502 cites W2051447718 @default.
• W1999558502 cites W2055916414 @default.
• W1999558502 cites W2056694568 @default.
• W1999558502 cites W2058455582 @default.
• W1999558502 cites W2059369537 @default.
• W1999558502 cites W2060847787 @default.
• W1999558502 cites W2060989736 @default.
• W1999558502 cites W2061708109 @default.
• W1999558502 cites W2062740984 @default.
• W1999558502 cites W2064286057 @default.
• W1999558502 cites W2068005545 @default.
• W1999558502 cites W2069526544 @default.
• W1999558502 cites W2073890849 @default.
• W1999558502 cites W2077245229 @default.
• W1999558502 cites W2079244266 @default.
• W1999558502 cites W2079554167 @default.
• W1999558502 cites W2081931352 @default.
• W1999558502 cites W2088059602 @default.
• W1999558502 cites W2092678842 @default.
• W1999558502 cites W2114322030 @default.
• W1999558502 cites W2129132447 @default.
• W1999558502 cites W2131602566 @default.
• W1999558502 cites W2143127916 @default.
• W1999558502 cites W2146196910 @default.
• W1999558502 cites W2151869895 @default.
• W1999558502 cites W2160207920 @default.
• W1999558502 cites W2162804111 @default.
• W1999558502 cites W2172113665 @default.
• W1999558502 cites W2321309748 @default.
• W1999558502 cites W2322088294 @default.
• W1999558502 cites W2327269495 @default.
• W1999558502 cites W2947402221 @default.
• W1999558502 cites W4238239709 @default.
• W1999558502 cites W4248223422 @default.
• W1999558502 cites W4256326007 @default.
• W1999558502 doi "https://doi.org/10.1097/00006123-199812000-00086" @default.
• W1999558502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9848855" @default.
• W1999558502 hasPublicationYear "1998" @default.
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