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- W1999561231 abstract "<h3>Abstract</h3> The application of Cas9 for genetic and epigenetic therapies in humans raises concerns over immunogenicity of this foreign protein. We report pre-existing human CD8+ T cell immunity to <i>Streptococcus pyogenes</i> Cas9 in the majority of healthy individuals screened. In a proof-of-principle study, we demonstrate that Cas9 protein can be modified to eliminate immunodominant epitopes through targeted mutation while preserving its function and specificity." @default.
- W1999561231 created "2016-06-24" @default.
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- W1999561231 date "2002-03-23" @default.
- W1999561231 modified "2023-09-25" @default.
- W1999561231 title "Influx of fake drugs to Nigeria worries health experts" @default.
- W1999561231 doi "https://doi.org/10.1136/bmj.324.7339.698" @default.
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