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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999562007> ?p ?o ?g. }

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• W1999562007 abstract "The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC50 = 0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectivity against other PDE family members. Rat pharmacokinetics and tissue distribution are also summarized." @default.
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• W1999562007 date "2010-09-01" @default.
• W1999562007 modified "2023-10-15" @default.
• W1999562007 title "The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors" @default.
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• W1999562007 doi "https://doi.org/10.1016/j.bmcl.2010.07.076" @default.
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