FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999562392> ?p ?o ?g. }

• W1999562392 endingPage "2582" @default.
• W1999562392 startingPage "2572" @default.
• W1999562392 abstract "Abstract The induction of cyclooxygenase‐2 (COX‐2) protein expression was assessed in human polymorphonuclear leukocytes (PMN) stimulated via receptors of the innate immune system. Peptidoglycan (PGN) and mannan, and at a lower extent the bacterial lipoprotein mimic palmitoyl‐3‐cysteine‐serine‐lysine‐4, induced COX‐2 protein expression. In contrast, lipoteichoic acid and muramyldipeptide were irrelevant stimuli. The mRNA encoding COX‐2 was present in resting PMN at an extent quite similar to that detected in stimulated PMN, whereas the expression of COX‐2 protein was undetectable. Treatment with the phosphatidylinositol 3‐kinase inhibitor (PI3K) wortmaninn, the mammalian target of rapamycin (mTOR) inhibitor rapamycin, and the translation inhibitor cycloheximide blocked the induction of COX‐2 protein in response to mannan and PGN, whereas the transcriptional inhibitor actinomycin D did not show a significant effect. These results disclose a capability of pathogen‐associated molecular patterns to induce the oxidative metabolism of arachidonic acid more robust than that of PMN archetypal chemoattractants, since mannan and PGN make it coincidental the release of arachidonic acid with a rapid induction of COX‐2 protein regulated by a signaling cascade involving PI3K, mTOR, and the translation machinery. This mechanism of COX‐2 protein induction expression in PMN is substantially different from that operative in mononuclear phagocytes, which is highly dependent on transcriptional regulation." @default.
• W1999562392 created "2016-06-24" @default.
• W1999562392 creator A5000201213 @default.
• W1999562392 creator A5005800974 @default.
• W1999562392 creator A5012402337 @default.
• W1999562392 creator A5030862473 @default.
• W1999562392 creator A5081288634 @default.
• W1999562392 date "2007-08-27" @default.
• W1999562392 modified "2023-10-18" @default.
• W1999562392 title "Mannan and peptidoglycan induce COX-2 protein in human PMNvia the mammalian target of rapamycin" @default.
• W1999562392 cites W1482128986 @default.
• W1999562392 cites W1486027616 @default.
• W1999562392 cites W1504931939 @default.
• W1999562392 cites W1509625360 @default.
• W1999562392 cites W1535636554 @default.
• W1999562392 cites W1544157645 @default.
• W1999562392 cites W1608041394 @default.
• W1999562392 cites W1698171640 @default.
• W1999562392 cites W1906542005 @default.
• W1999562392 cites W1913937884 @default.
• W1999562392 cites W1939723417 @default.
• W1999562392 cites W1949632792 @default.
• W1999562392 cites W1965313627 @default.
• W1999562392 cites W1966103571 @default.
• W1999562392 cites W1970190307 @default.
• W1999562392 cites W1971900170 @default.
• W1999562392 cites W1986473192 @default.
• W1999562392 cites W1996242613 @default.
• W1999562392 cites W1997839876 @default.
• W1999562392 cites W1998894507 @default.
• W1999562392 cites W1999324225 @default.
• W1999562392 cites W1999681551 @default.
• W1999562392 cites W1999855516 @default.
• W1999562392 cites W2004465286 @default.
• W1999562392 cites W2009364588 @default.
• W1999562392 cites W2011677296 @default.
• W1999562392 cites W2015178998 @default.
• W1999562392 cites W2019209562 @default.
• W1999562392 cites W2020425601 @default.
• W1999562392 cites W2025763720 @default.
• W1999562392 cites W2029024519 @default.
• W1999562392 cites W2029845836 @default.
• W1999562392 cites W2032386882 @default.
• W1999562392 cites W2043934481 @default.
• W1999562392 cites W2056525578 @default.
• W1999562392 cites W2076024460 @default.
• W1999562392 cites W2086899319 @default.
• W1999562392 cites W2098313671 @default.
• W1999562392 cites W2106729611 @default.
• W1999562392 cites W2108244474 @default.
• W1999562392 cites W2108661081 @default.
• W1999562392 cites W2121474571 @default.
• W1999562392 cites W2126880379 @default.
• W1999562392 cites W2130946949 @default.
• W1999562392 cites W2132482634 @default.
• W1999562392 cites W2141157874 @default.
• W1999562392 cites W2148712834 @default.
• W1999562392 cites W2157339124 @default.
• W1999562392 cites W2157985992 @default.
• W1999562392 cites W2160270312 @default.
• W1999562392 cites W2163382569 @default.
• W1999562392 cites W2165241116 @default.
• W1999562392 cites W2167556553 @default.
• W1999562392 cites W2170533080 @default.
• W1999562392 cites W96531724 @default.
• W1999562392 doi "https://doi.org/10.1002/eji.200737262" @default.
• W1999562392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17683115" @default.
• W1999562392 hasPublicationYear "2007" @default.
• W1999562392 type Work @default.
• W1999562392 sameAs 1999562392 @default.
• W1999562392 citedByCount "7" @default.
• W1999562392 countsByYear W19995623922015 @default.
• W1999562392 countsByYear W19995623922018 @default.
• W1999562392 countsByYear W19995623922020 @default.
• W1999562392 crossrefType "journal-article" @default.
• W1999562392 hasAuthorship W1999562392A5000201213 @default.
• W1999562392 hasAuthorship W1999562392A5005800974 @default.
• W1999562392 hasAuthorship W1999562392A5012402337 @default.
• W1999562392 hasAuthorship W1999562392A5030862473 @default.
• W1999562392 hasAuthorship W1999562392A5081288634 @default.
• W1999562392 hasBestOaLocation W19995623921 @default.
• W1999562392 hasConcept C181199279 @default.
• W1999562392 hasConcept C184235292 @default.
• W1999562392 hasConcept C2776634448 @default.
• W1999562392 hasConcept C2778078955 @default.
• W1999562392 hasConcept C2778128677 @default.
• W1999562392 hasConcept C2779489039 @default.
• W1999562392 hasConcept C3675279 @default.
• W1999562392 hasConcept C523546767 @default.
• W1999562392 hasConcept C54355233 @default.
• W1999562392 hasConcept C55493867 @default.
• W1999562392 hasConcept C62478195 @default.
• W1999562392 hasConcept C6977687 @default.
• W1999562392 hasConcept C86554907 @default.
• W1999562392 hasConcept C86803240 @default.
• W1999562392 hasConcept C95444343 @default.
• W1999562392 hasConcept C97029542 @default.
• W1999562392 hasConceptScore W1999562392C181199279 @default.

• next