FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999568052> ?p ?o ?g. }

• W1999568052 endingPage "184" @default.
• W1999568052 startingPage "177" @default.
• W1999568052 abstract "Serotonergic dysfunction has been hypothesized to play an important role in the pathophysiology of alcoholism. However, whether congenital serotonin (5-HT) deficiency leads to increased alcohol consumption or affects ethanol-related behaviors has not been established. Here, we use a transgenic mouse line that expresses a hypofunctional variant of the 5-HT synthesis enzyme, tryptophan hydroxylase 2, to examine the impact of 5-HT deficiency on responses to alcohol. We demonstrate that these 5-HT-deficient transgenic animals (Tph2KI mice) recover their righting reflex more rapidly than wild-type controls following a high dose of ethanol and exhibit blunted locomotor retardation in response to repeated ethanol administration. In addition, compared to WT controls, 5-HT-deficient animals consume significantly more ethanol and exhibit increased preference for ethanol in two-bottle choice tests. Our data also suggest that 5-HT plays a critical role in mediating the effects of ethanol on Akt/GSK3β signaling in the nucleus accumbens. Overall, our results corroborate previous theories regarding the importance of brain 5-HT levels in mediating responsiveness to alcohol and demonstrate, for the first time, that congenital 5-HT deficiency leads to increased ethanol consumption and decreased sensitivity to the sedative-like effects of ethanol, perhaps in part through modulating Akt/GSK3β signaling." @default.
• W1999568052 created "2016-06-24" @default.
• W1999568052 creator A5007698609 @default.
• W1999568052 creator A5068123089 @default.
• W1999568052 creator A5077422222 @default.
• W1999568052 date "2014-02-01" @default.
• W1999568052 modified "2023-10-16" @default.
• W1999568052 title "Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice" @default.
• W1999568052 cites W140784171 @default.
• W1999568052 cites W14199531 @default.
• W1999568052 cites W1497441168 @default.
• W1999568052 cites W1964021320 @default.
• W1999568052 cites W1969669320 @default.
• W1999568052 cites W1969763801 @default.
• W1999568052 cites W1971300725 @default.
• W1999568052 cites W1971382941 @default.
• W1999568052 cites W1972471305 @default.
• W1999568052 cites W1973373241 @default.
• W1999568052 cites W1977160269 @default.
• W1999568052 cites W1982713269 @default.
• W1999568052 cites W1983111430 @default.
• W1999568052 cites W1985071696 @default.
• W1999568052 cites W1991054433 @default.
• W1999568052 cites W1994516975 @default.
• W1999568052 cites W1995120027 @default.
• W1999568052 cites W1999254082 @default.
• W1999568052 cites W2001660552 @default.
• W1999568052 cites W2004984114 @default.
• W1999568052 cites W2005820090 @default.
• W1999568052 cites W2005867593 @default.
• W1999568052 cites W2012902192 @default.
• W1999568052 cites W2013274461 @default.
• W1999568052 cites W2027323411 @default.
• W1999568052 cites W2028595610 @default.
• W1999568052 cites W2029707852 @default.
• W1999568052 cites W2041531700 @default.
• W1999568052 cites W2055908231 @default.
• W1999568052 cites W2057588533 @default.
• W1999568052 cites W2058613739 @default.
• W1999568052 cites W2058702631 @default.
• W1999568052 cites W2062239829 @default.
• W1999568052 cites W2072830432 @default.
• W1999568052 cites W2073314272 @default.
• W1999568052 cites W2080032809 @default.
• W1999568052 cites W2087786037 @default.
• W1999568052 cites W2090609922 @default.
• W1999568052 cites W2100720632 @default.
• W1999568052 cites W2101966295 @default.
• W1999568052 cites W2138546215 @default.
• W1999568052 cites W2150987694 @default.
• W1999568052 cites W2170207964 @default.
• W1999568052 cites W2338719804 @default.
• W1999568052 doi "https://doi.org/10.1016/j.neuropharm.2013.09.010" @default.
• W1999568052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3874885" @default.
• W1999568052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24067926" @default.
• W1999568052 hasPublicationYear "2014" @default.
• W1999568052 type Work @default.
• W1999568052 sameAs 1999568052 @default.
• W1999568052 citedByCount "22" @default.
• W1999568052 countsByYear W19995680522015 @default.
• W1999568052 countsByYear W19995680522016 @default.
• W1999568052 countsByYear W19995680522018 @default.
• W1999568052 countsByYear W19995680522019 @default.
• W1999568052 countsByYear W19995680522020 @default.
• W1999568052 countsByYear W19995680522021 @default.
• W1999568052 countsByYear W19995680522022 @default.
• W1999568052 crossrefType "journal-article" @default.
• W1999568052 hasAuthorship W1999568052A5007698609 @default.
• W1999568052 hasAuthorship W1999568052A5068123089 @default.
• W1999568052 hasAuthorship W1999568052A5077422222 @default.
• W1999568052 hasBestOaLocation W19995680522 @default.
• W1999568052 hasConcept C126322002 @default.
• W1999568052 hasConcept C131783052 @default.
• W1999568052 hasConcept C134018914 @default.
• W1999568052 hasConcept C15744967 @default.
• W1999568052 hasConcept C170493617 @default.
• W1999568052 hasConcept C185592680 @default.
• W1999568052 hasConcept C2775864247 @default.
• W1999568052 hasConcept C2775951788 @default.
• W1999568052 hasConcept C2776552330 @default.
• W1999568052 hasConcept C2779999352 @default.
• W1999568052 hasConcept C2780161600 @default.
• W1999568052 hasConcept C37000724 @default.
• W1999568052 hasConcept C513476851 @default.
• W1999568052 hasConcept C55493867 @default.
• W1999568052 hasConcept C71924100 @default.
• W1999568052 hasConcept C83974742 @default.
• W1999568052 hasConceptScore W1999568052C126322002 @default.
• W1999568052 hasConceptScore W1999568052C131783052 @default.
• W1999568052 hasConceptScore W1999568052C134018914 @default.
• W1999568052 hasConceptScore W1999568052C15744967 @default.
• W1999568052 hasConceptScore W1999568052C170493617 @default.
• W1999568052 hasConceptScore W1999568052C185592680 @default.
• W1999568052 hasConceptScore W1999568052C2775864247 @default.
• W1999568052 hasConceptScore W1999568052C2775951788 @default.
• W1999568052 hasConceptScore W1999568052C2776552330 @default.
• W1999568052 hasConceptScore W1999568052C2779999352 @default.
• W1999568052 hasConceptScore W1999568052C2780161600 @default.

• next