FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999576323> ?p ?o ?g. }

• W1999576323 endingPage "419" @default.
• W1999576323 startingPage "413" @default.
• W1999576323 abstract "There is increasing evidence that extracellular nucleotides act on bone cells via multiple P2 receptors. The naturally-occurring ligand ATP is a potent agonist at all receptor subtypes, whereas ADP and UTP only act at specific receptor subtypes. We have reported that the formation and resorptive activity of rodent osteoclasts are stimulated powerfully by both extracellular ATP and its first degradation product, ADP, the latter acting at nanomolar concentrations, probably via the P2Y1 receptor subtype. In the present study, we investigated the actions of ATP, ADP, adenosine, and UTP on osteoblastic function. In 16-21 day cultures of primary rat calvarial osteoblasts, ADP and the selective P2Y1 agonist 2-methylthioADP were without effect on bone nodule formation at concentrations between 1 and 125 microM, as was adenosine. However, UTP, a P2Y2 and P2Y4 receptor agonist, known to be without effect on osteoclast function, strongly inhibited bone nodule formation at concentrations >or= 1 microM. ATP was inhibitory at >or= 10 microM. Rat osteoblasts express P2Y2, but not P2Y4 receptor mRNA, as determined by in situ hybridization. Thus, the low-dose effects of extracellular nucleotides on bone formation and bone resorption appear to be mediated via different P2Y receptor subtypes: ADP, signalling through the P2Y1 receptor on both osteoclasts and osteoblasts, is a powerful stimulator of osteoclast formation and activity, whereas UTP, signalling via the P2Y2 receptor on osteoblasts, blocks bone formation by osteoblasts. ATP, the 'universal' agonist, can simultaneously stimulate resorption and inhibit bone formation. These findings suggest that extracellular nucleotides could function locally as important negative modulators of bone metabolism, perhaps contributing to bone loss in a number of pathological states." @default.
• W1999576323 created "2016-06-24" @default.
• W1999576323 creator A5025679809 @default.
• W1999576323 creator A5032236815 @default.
• W1999576323 creator A5058369958 @default.
• W1999576323 creator A5074116768 @default.
• W1999576323 date "2002-01-01" @default.
• W1999576323 modified "2023-09-26" @default.
• W1999576323 title "ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: A novel role for the P2Y2 receptor in bone remodeling" @default.
• W1999576323 cites W1964243809 @default.
• W1999576323 cites W1968834775 @default.
• W1999576323 cites W1971719973 @default.
• W1999576323 cites W1976406251 @default.
• W1999576323 cites W1976961529 @default.
• W1999576323 cites W1980927246 @default.
• W1999576323 cites W1985080645 @default.
• W1999576323 cites W1985167985 @default.
• W1999576323 cites W1993029609 @default.
• W1999576323 cites W2006385943 @default.
• W1999576323 cites W2007902637 @default.
• W1999576323 cites W2014278192 @default.
• W1999576323 cites W2020188591 @default.
• W1999576323 cites W2027765902 @default.
• W1999576323 cites W2028289811 @default.
• W1999576323 cites W2036950738 @default.
• W1999576323 cites W2040724553 @default.
• W1999576323 cites W2044232232 @default.
• W1999576323 cites W2047140597 @default.
• W1999576323 cites W2051792551 @default.
• W1999576323 cites W2055588653 @default.
• W1999576323 cites W2056687222 @default.
• W1999576323 cites W2068285705 @default.
• W1999576323 cites W2069004519 @default.
• W1999576323 cites W2080188617 @default.
• W1999576323 cites W2080742455 @default.
• W1999576323 cites W2091042230 @default.
• W1999576323 cites W2104661115 @default.
• W1999576323 cites W2138736783 @default.
• W1999576323 cites W2261511021 @default.
• W1999576323 cites W2414372457 @default.
• W1999576323 cites W54538561 @default.
• W1999576323 doi "https://doi.org/10.1002/jcb.10236" @default.
• W1999576323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12210747" @default.
• W1999576323 hasPublicationYear "2002" @default.
• W1999576323 type Work @default.
• W1999576323 sameAs 1999576323 @default.
• W1999576323 citedByCount "105" @default.
• W1999576323 countsByYear W19995763232012 @default.
• W1999576323 countsByYear W19995763232013 @default.
• W1999576323 countsByYear W19995763232014 @default.
• W1999576323 countsByYear W19995763232015 @default.
• W1999576323 countsByYear W19995763232016 @default.
• W1999576323 countsByYear W19995763232017 @default.
• W1999576323 countsByYear W19995763232018 @default.
• W1999576323 countsByYear W19995763232019 @default.
• W1999576323 countsByYear W19995763232020 @default.
• W1999576323 countsByYear W19995763232022 @default.
• W1999576323 countsByYear W19995763232023 @default.
• W1999576323 crossrefType "journal-article" @default.
• W1999576323 hasAuthorship W1999576323A5025679809 @default.
• W1999576323 hasAuthorship W1999576323A5032236815 @default.
• W1999576323 hasAuthorship W1999576323A5058369958 @default.
• W1999576323 hasAuthorship W1999576323A5074116768 @default.
• W1999576323 hasConcept C126322002 @default.
• W1999576323 hasConcept C134018914 @default.
• W1999576323 hasConcept C146562846 @default.
• W1999576323 hasConcept C160225129 @default.
• W1999576323 hasConcept C170033053 @default.
• W1999576323 hasConcept C170493617 @default.
• W1999576323 hasConcept C185592680 @default.
• W1999576323 hasConcept C202751555 @default.
• W1999576323 hasConcept C2776033226 @default.
• W1999576323 hasConcept C2776991684 @default.
• W1999576323 hasConcept C2778260815 @default.
• W1999576323 hasConcept C2778938600 @default.
• W1999576323 hasConcept C2780410667 @default.
• W1999576323 hasConcept C28406088 @default.
• W1999576323 hasConcept C55493867 @default.
• W1999576323 hasConcept C57306754 @default.
• W1999576323 hasConcept C673006 @default.
• W1999576323 hasConcept C71924100 @default.
• W1999576323 hasConcept C86803240 @default.
• W1999576323 hasConcept C95444343 @default.
• W1999576323 hasConceptScore W1999576323C126322002 @default.
• W1999576323 hasConceptScore W1999576323C134018914 @default.
• W1999576323 hasConceptScore W1999576323C146562846 @default.
• W1999576323 hasConceptScore W1999576323C160225129 @default.
• W1999576323 hasConceptScore W1999576323C170033053 @default.
• W1999576323 hasConceptScore W1999576323C170493617 @default.
• W1999576323 hasConceptScore W1999576323C185592680 @default.
• W1999576323 hasConceptScore W1999576323C202751555 @default.
• W1999576323 hasConceptScore W1999576323C2776033226 @default.
• W1999576323 hasConceptScore W1999576323C2776991684 @default.
• W1999576323 hasConceptScore W1999576323C2778260815 @default.
• W1999576323 hasConceptScore W1999576323C2778938600 @default.
• W1999576323 hasConceptScore W1999576323C2780410667 @default.
• W1999576323 hasConceptScore W1999576323C28406088 @default.
• W1999576323 hasConceptScore W1999576323C55493867 @default.

• next