Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999576398> ?p ?o ?g. }
- W1999576398 endingPage "9578" @default.
- W1999576398 startingPage "9574" @default.
- W1999576398 abstract "In a previous paper, a model was presented showing how the group of Ca2+/calmodulin-dependent protein kinase II molecules contained within a postsynaptic density could stably store a graded synaptic weight. This paper completes the model by showing how bidirectional control of synaptic weight could be achieved. It is proposed that the quantitative level of the activity-dependent rise in postsynaptic Ca2+ determines whether the synaptic weight will increase or decrease. It is further proposed that reduction of synaptic weight is governed by protein phosphatase 1, an enzyme indirectly controlled by Ca2+ through reactions involving phosphatase inhibitor 1, cAMP-dependent protein kinase, calcineurin, and adenylate cyclase. Modeling of this biochemical system shows that it can function as an analog computer that can store a synaptic weight and modify it in accord with the Hebb and anti-Hebb learning rules." @default.
- W1999576398 created "2016-06-24" @default.
- W1999576398 creator A5071574342 @default.
- W1999576398 date "1989-12-01" @default.
- W1999576398 modified "2023-10-14" @default.
- W1999576398 title "A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory." @default.
- W1999576398 cites W1518396254 @default.
- W1999576398 cites W1526180724 @default.
- W1999576398 cites W1527409442 @default.
- W1999576398 cites W1643311486 @default.
- W1999576398 cites W1700879768 @default.
- W1999576398 cites W1733248925 @default.
- W1999576398 cites W1926846042 @default.
- W1999576398 cites W1965385102 @default.
- W1999576398 cites W1969749384 @default.
- W1999576398 cites W1972789122 @default.
- W1999576398 cites W1973435759 @default.
- W1999576398 cites W1976054166 @default.
- W1999576398 cites W1976344568 @default.
- W1999576398 cites W1976645516 @default.
- W1999576398 cites W1988832534 @default.
- W1999576398 cites W1990969569 @default.
- W1999576398 cites W1995484013 @default.
- W1999576398 cites W1996088954 @default.
- W1999576398 cites W1997568797 @default.
- W1999576398 cites W1998751065 @default.
- W1999576398 cites W1999488417 @default.
- W1999576398 cites W2009782005 @default.
- W1999576398 cites W2010526455 @default.
- W1999576398 cites W2010920096 @default.
- W1999576398 cites W2010926499 @default.
- W1999576398 cites W2019203033 @default.
- W1999576398 cites W2019962936 @default.
- W1999576398 cites W2023368112 @default.
- W1999576398 cites W2028519419 @default.
- W1999576398 cites W2031739172 @default.
- W1999576398 cites W2033942553 @default.
- W1999576398 cites W2041117252 @default.
- W1999576398 cites W2041380326 @default.
- W1999576398 cites W2047468613 @default.
- W1999576398 cites W2057315110 @default.
- W1999576398 cites W2058148599 @default.
- W1999576398 cites W2061893190 @default.
- W1999576398 cites W2062474690 @default.
- W1999576398 cites W2069713657 @default.
- W1999576398 cites W2080480553 @default.
- W1999576398 cites W2081445047 @default.
- W1999576398 cites W2081966223 @default.
- W1999576398 cites W2087445908 @default.
- W1999576398 cites W2094474445 @default.
- W1999576398 cites W2098314540 @default.
- W1999576398 cites W2102459797 @default.
- W1999576398 cites W2128084896 @default.
- W1999576398 cites W2131921751 @default.
- W1999576398 cites W2394619739 @default.
- W1999576398 cites W2403704540 @default.
- W1999576398 cites W60602641 @default.
- W1999576398 doi "https://doi.org/10.1073/pnas.86.23.9574" @default.
- W1999576398 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/298540" @default.
- W1999576398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2556718" @default.
- W1999576398 hasPublicationYear "1989" @default.
- W1999576398 type Work @default.
- W1999576398 sameAs 1999576398 @default.
- W1999576398 citedByCount "984" @default.
- W1999576398 countsByYear W19995763982012 @default.
- W1999576398 countsByYear W19995763982013 @default.
- W1999576398 countsByYear W19995763982014 @default.
- W1999576398 countsByYear W19995763982015 @default.
- W1999576398 countsByYear W19995763982016 @default.
- W1999576398 countsByYear W19995763982017 @default.
- W1999576398 countsByYear W19995763982018 @default.
- W1999576398 countsByYear W19995763982019 @default.
- W1999576398 countsByYear W19995763982020 @default.
- W1999576398 countsByYear W19995763982021 @default.
- W1999576398 countsByYear W19995763982022 @default.
- W1999576398 countsByYear W19995763982023 @default.
- W1999576398 crossrefType "journal-article" @default.
- W1999576398 hasAuthorship W1999576398A5071574342 @default.
- W1999576398 hasBestOaLocation W19995763981 @default.
- W1999576398 hasConcept C12554922 @default.
- W1999576398 hasConcept C126322002 @default.
- W1999576398 hasConcept C128057223 @default.
- W1999576398 hasConcept C169760540 @default.
- W1999576398 hasConcept C170493617 @default.
- W1999576398 hasConcept C178666793 @default.
- W1999576398 hasConcept C180526460 @default.
- W1999576398 hasConcept C181199279 @default.
- W1999576398 hasConcept C185592680 @default.
- W1999576398 hasConcept C187541742 @default.
- W1999576398 hasConcept C197341189 @default.
- W1999576398 hasConcept C200170125 @default.
- W1999576398 hasConcept C2780069284 @default.
- W1999576398 hasConcept C2911091166 @default.
- W1999576398 hasConcept C29688787 @default.
- W1999576398 hasConcept C2993285035 @default.
- W1999576398 hasConcept C41008148 @default.
- W1999576398 hasConcept C55493867 @default.
- W1999576398 hasConcept C71924100 @default.