Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999589177> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1999589177 endingPage "530" @default.
- W1999589177 startingPage "520" @default.
- W1999589177 abstract "Lormetazepam, an investigational hypnotic, was evaluated for efficacy and withdrawal phenomena in doses of 0.5, 1.0, 1.5, and 2.0 mg in four separate sleep laboratory protocols, each including four placebo baseline nights, seven drug nights, and three placebo withdrawal nights. A moderate degree of efficacy was shown across the four doses, but this was quite variable. There was no dose-response effect for efficacy for either the first three or last three nights of this short-term administration period. In general, there was less efficacy on the later drug nights, indicating a potential for the development of tolerance over a relatively short period of time. Following drug withdrawal, there was a dose-related worsening of sleep above baseline levels (rebound insomnia). The peak degree of worsening of sleep following drug withdrawal was more than two times greater than the peak degree of improvement of sleep with drug administration." @default.
- W1999589177 created "2016-06-24" @default.
- W1999589177 creator A5000066478 @default.
- W1999589177 creator A5045768758 @default.
- W1999589177 creator A5059575944 @default.
- W1999589177 creator A5064915306 @default.
- W1999589177 creator A5091558904 @default.
- W1999589177 date "1982-11-12" @default.
- W1999589177 modified "2023-10-18" @default.
- W1999589177 title "Dose-Response Studies of Lormetazepam: Efficacy, Side Effects, and Rebound Insomnia" @default.
- W1999589177 cites W1966581042 @default.
- W1999589177 cites W1978774989 @default.
- W1999589177 cites W1979743062 @default.
- W1999589177 cites W1996341365 @default.
- W1999589177 cites W2023319612 @default.
- W1999589177 cites W2027395047 @default.
- W1999589177 cites W2049309469 @default.
- W1999589177 cites W2055220982 @default.
- W1999589177 cites W2056572339 @default.
- W1999589177 cites W2061554433 @default.
- W1999589177 cites W2068751246 @default.
- W1999589177 cites W2094595978 @default.
- W1999589177 cites W2160743614 @default.
- W1999589177 cites W2184665383 @default.
- W1999589177 cites W2414282949 @default.
- W1999589177 cites W4233643509 @default.
- W1999589177 cites W4242431061 @default.
- W1999589177 cites W4376542689 @default.
- W1999589177 doi "https://doi.org/10.1002/j.1552-4604.1982.tb02645.x" @default.
- W1999589177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6131080" @default.
- W1999589177 hasPublicationYear "1982" @default.
- W1999589177 type Work @default.
- W1999589177 sameAs 1999589177 @default.
- W1999589177 citedByCount "33" @default.
- W1999589177 countsByYear W19995891772017 @default.
- W1999589177 countsByYear W19995891772023 @default.
- W1999589177 crossrefType "journal-article" @default.
- W1999589177 hasAuthorship W1999589177A5000066478 @default.
- W1999589177 hasAuthorship W1999589177A5045768758 @default.
- W1999589177 hasAuthorship W1999589177A5059575944 @default.
- W1999589177 hasAuthorship W1999589177A5064915306 @default.
- W1999589177 hasAuthorship W1999589177A5091558904 @default.
- W1999589177 hasConcept C142724271 @default.
- W1999589177 hasConcept C204787440 @default.
- W1999589177 hasConcept C27081682 @default.
- W1999589177 hasConcept C2778062832 @default.
- W1999589177 hasConcept C2779985140 @default.
- W1999589177 hasConcept C2780035454 @default.
- W1999589177 hasConcept C2780930544 @default.
- W1999589177 hasConcept C2781210498 @default.
- W1999589177 hasConcept C2987276129 @default.
- W1999589177 hasConcept C2992459003 @default.
- W1999589177 hasConcept C42219234 @default.
- W1999589177 hasConcept C71924100 @default.
- W1999589177 hasConcept C98274493 @default.
- W1999589177 hasConceptScore W1999589177C142724271 @default.
- W1999589177 hasConceptScore W1999589177C204787440 @default.
- W1999589177 hasConceptScore W1999589177C27081682 @default.
- W1999589177 hasConceptScore W1999589177C2778062832 @default.
- W1999589177 hasConceptScore W1999589177C2779985140 @default.
- W1999589177 hasConceptScore W1999589177C2780035454 @default.
- W1999589177 hasConceptScore W1999589177C2780930544 @default.
- W1999589177 hasConceptScore W1999589177C2781210498 @default.
- W1999589177 hasConceptScore W1999589177C2987276129 @default.
- W1999589177 hasConceptScore W1999589177C2992459003 @default.
- W1999589177 hasConceptScore W1999589177C42219234 @default.
- W1999589177 hasConceptScore W1999589177C71924100 @default.
- W1999589177 hasConceptScore W1999589177C98274493 @default.
- W1999589177 hasIssue "11" @default.
- W1999589177 hasLocation W19995891771 @default.
- W1999589177 hasLocation W19995891772 @default.
- W1999589177 hasOpenAccess W1999589177 @default.
- W1999589177 hasPrimaryLocation W19995891771 @default.
- W1999589177 hasRelatedWork W1979743062 @default.
- W1999589177 hasRelatedWork W1999589177 @default.
- W1999589177 hasRelatedWork W2018819062 @default.
- W1999589177 hasRelatedWork W2036948497 @default.
- W1999589177 hasRelatedWork W2135271676 @default.
- W1999589177 hasRelatedWork W2161971851 @default.
- W1999589177 hasRelatedWork W2327690715 @default.
- W1999589177 hasRelatedWork W2394879102 @default.
- W1999589177 hasRelatedWork W2399720854 @default.
- W1999589177 hasRelatedWork W2415006446 @default.
- W1999589177 hasVolume "22" @default.
- W1999589177 isParatext "false" @default.
- W1999589177 isRetracted "false" @default.
- W1999589177 magId "1999589177" @default.
- W1999589177 workType "article" @default.