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- W1999589247 abstract "The newborn has enhanced susceptibility to viral infection, in part due to defects in cellular cytotoxicity (CC). The placenta serves as a barrier between mother and fetus, containing many immune cells whose functional capabilities have not been well characterized. Thus, we assessed phenotypic and functional capabilities of these cells. Placentas obtained within 5 hours from 16 deliveries were minced and digested in collagenase and DNase. Mononuclear cells (MC) were separated by differential centrifugation with average yield of 106 MC/gm of tissue with > 80% viability. Separated MC consisted of lymphocytes, mean 51% (range 20-81%) monocytes 25% (0-67%), and other cells including polys and trophoblasts. E rosette forming cells made up 63% (56-75%), while SMIg positive cells made up 9% (3-18%) of the MC. Monoclonal antibody characterization of MC surface phenotype yielded mean 25% with anti-pan T cell Ab, 20% with anti-DR Ab, 7% with anti-myeloid cell Ab. Cytotoxic studies including lectin dependent CC using EL-4 target ranged from 11-14% (nl adult 29-38%). Antibody dependent CC using Raji target ranged from 7-19% (nl adult 11-44%). Natural killer CC using Molt 4f target at effector:target of 50:1 yielded 37±7.4% lysis compared to adult control of 48±6.5% (NS). Using K562 target, specific lysis by placental MC was 9.9±3.5% compared to adult control of 44±8.9% (p<.01). This defective cytotoxic response to K562 parallels the NK cytotoxic defect of cord MC." @default.
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- W1999589247 date "1984-04-01" @default.
- W1999589247 modified "2023-09-26" @default.
- W1999589247 title "PLACENTAL NATURAL KILLER CYTOTOXICITY PARALLELS THAT OF CORD BLOOD" @default.
- W1999589247 doi "https://doi.org/10.1203/00006450-198404001-00976" @default.
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