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- W1999594546 endingPage "20130109" @default.
- W1999594546 startingPage "20130109" @default.
- W1999594546 abstract "Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis." @default.
- W1999594546 created "2016-06-24" @default.
- W1999594546 creator A5022507661 @default.
- W1999594546 creator A5057480772 @default.
- W1999594546 date "2014-03-19" @default.
- W1999594546 modified "2023-10-06" @default.
- W1999594546 title "Ion channels and transporters in the development of drug resistance in cancer cells" @default.
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- W1999594546 doi "https://doi.org/10.1098/rstb.2013.0109" @default.
- W1999594546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3917363" @default.
- W1999594546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24493757" @default.
- W1999594546 hasPublicationYear "2014" @default.
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