Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999608535> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1999608535 endingPage "331" @default.
- W1999608535 startingPage "319" @default.
- W1999608535 abstract "Underwriting the risk of rare disorders in long-term insurance often relies on rates of onset estimated from quite small epidemiological studies. These estimates can have considerable sampling uncertainty and any function based upon them, such as a premium rate, is also an estimate subject to uncertainty. This is particularly relevant in the case of genetic disorders, because the acceptable use of genetic information may depend on establishing its reliability as a measure of risk. The sampling distribution of a premium rate is hard to estimate without access to the original data, which is rarely possible. From two studies of adult polycystic kidney disease (APKD) we obtain, not the original data, but the cases and exposures used for Kaplan–Meier estimates of the survival probability. We use three resampling methods with these data, namely: (a) the standard bootstrap; (b) the weird bootstrap; and (c) simulation of censored random lifetimes. Rates of onset were obtained from each simulated sample using kernel-smoothed Nelson–Aalen estimates, hence critical illness insurance premium rates for a mutation carrier or a member of an affected family. From 10,000 such samples we estimate the sampling distributions of the premium rates, finding considerable uncertainty. Very careful consideration should be given before using small-sample epidemiological data to deal with insurance problems." @default.
- W1999608535 created "2016-06-24" @default.
- W1999608535 creator A5003733647 @default.
- W1999608535 creator A5030138412 @default.
- W1999608535 creator A5067830647 @default.
- W1999608535 date "2008-02-01" @default.
- W1999608535 modified "2023-09-26" @default.
- W1999608535 title "Premium rates based on genetic studies: How reliable are they?" @default.
- W1999608535 cites W1271557530 @default.
- W1999608535 cites W1924478590 @default.
- W1999608535 cites W1967633949 @default.
- W1999608535 cites W1995945562 @default.
- W1999608535 cites W1997092778 @default.
- W1999608535 cites W2012159432 @default.
- W1999608535 cites W2017071447 @default.
- W1999608535 cites W2045602503 @default.
- W1999608535 cites W2049029699 @default.
- W1999608535 cites W2057579648 @default.
- W1999608535 cites W2057968703 @default.
- W1999608535 cites W2062201965 @default.
- W1999608535 cites W2078740257 @default.
- W1999608535 cites W2079621390 @default.
- W1999608535 cites W2082873028 @default.
- W1999608535 cites W2093986262 @default.
- W1999608535 cites W2097879961 @default.
- W1999608535 cites W2107958340 @default.
- W1999608535 cites W2117897510 @default.
- W1999608535 cites W2122714486 @default.
- W1999608535 cites W2160842550 @default.
- W1999608535 cites W2171435232 @default.
- W1999608535 cites W2172525224 @default.
- W1999608535 cites W2208740363 @default.
- W1999608535 cites W2293972327 @default.
- W1999608535 cites W2319384619 @default.
- W1999608535 cites W2494187188 @default.
- W1999608535 cites W796972684 @default.
- W1999608535 doi "https://doi.org/10.1016/j.insmatheco.2007.03.005" @default.
- W1999608535 hasPublicationYear "2008" @default.
- W1999608535 type Work @default.
- W1999608535 sameAs 1999608535 @default.
- W1999608535 citedByCount "4" @default.
- W1999608535 countsByYear W19996085352012 @default.
- W1999608535 crossrefType "journal-article" @default.
- W1999608535 hasAuthorship W1999608535A5003733647 @default.
- W1999608535 hasAuthorship W1999608535A5030138412 @default.
- W1999608535 hasAuthorship W1999608535A5067830647 @default.
- W1999608535 hasConcept C105795698 @default.
- W1999608535 hasConcept C107130276 @default.
- W1999608535 hasConcept C126322002 @default.
- W1999608535 hasConcept C149782125 @default.
- W1999608535 hasConcept C150921843 @default.
- W1999608535 hasConcept C162118730 @default.
- W1999608535 hasConcept C162324750 @default.
- W1999608535 hasConcept C177860879 @default.
- W1999608535 hasConcept C185429906 @default.
- W1999608535 hasConcept C26503482 @default.
- W1999608535 hasConcept C33923547 @default.
- W1999608535 hasConcept C41008148 @default.
- W1999608535 hasConcept C71924100 @default.
- W1999608535 hasConcept C81790035 @default.
- W1999608535 hasConceptScore W1999608535C105795698 @default.
- W1999608535 hasConceptScore W1999608535C107130276 @default.
- W1999608535 hasConceptScore W1999608535C126322002 @default.
- W1999608535 hasConceptScore W1999608535C149782125 @default.
- W1999608535 hasConceptScore W1999608535C150921843 @default.
- W1999608535 hasConceptScore W1999608535C162118730 @default.
- W1999608535 hasConceptScore W1999608535C162324750 @default.
- W1999608535 hasConceptScore W1999608535C177860879 @default.
- W1999608535 hasConceptScore W1999608535C185429906 @default.
- W1999608535 hasConceptScore W1999608535C26503482 @default.
- W1999608535 hasConceptScore W1999608535C33923547 @default.
- W1999608535 hasConceptScore W1999608535C41008148 @default.
- W1999608535 hasConceptScore W1999608535C71924100 @default.
- W1999608535 hasConceptScore W1999608535C81790035 @default.
- W1999608535 hasIssue "1" @default.
- W1999608535 hasLocation W19996085351 @default.
- W1999608535 hasOpenAccess W1999608535 @default.
- W1999608535 hasPrimaryLocation W19996085351 @default.
- W1999608535 hasRelatedWork W1983882984 @default.
- W1999608535 hasRelatedWork W1985810263 @default.
- W1999608535 hasRelatedWork W1989900574 @default.
- W1999608535 hasRelatedWork W1999608535 @default.
- W1999608535 hasRelatedWork W2054318125 @default.
- W1999608535 hasRelatedWork W2124181495 @default.
- W1999608535 hasRelatedWork W2188334062 @default.
- W1999608535 hasRelatedWork W2509200907 @default.
- W1999608535 hasRelatedWork W2739855606 @default.
- W1999608535 hasRelatedWork W3204051141 @default.
- W1999608535 hasVolume "42" @default.
- W1999608535 isParatext "false" @default.
- W1999608535 isRetracted "false" @default.
- W1999608535 magId "1999608535" @default.
- W1999608535 workType "article" @default.