Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999623745> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1999623745 endingPage "381" @default.
- W1999623745 startingPage "375" @default.
- W1999623745 abstract "Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior gradient 3 (AGR3) as a new diagnostic marker helping to distinguish between ICC and HCC. AGR3 is a putative transmembrane protein implicated in breast, prostate and ovary tumorigenesis and belongs to the family of protein disulfide isomerases. Since there is little information on how AGR3 is expressed in normal and diseased tissues and what its exact function is, we analyzed its expression pattern in normal liver and tumor tissue of ICC and HCC. The immunohistochemical analysis in normal tissue revealed specific AGR3 expression in intrahepatic bile duct cholangiocytes which was not present in liver hepatocytes. Consequently we analyzed AGR3 expression in 74 representative samples of puncture biopsies, tissue excisions and resection specimens from which 48 samples were diagnosed as HCC and 26 as ICC. Our results showed AGR3 expression negative and weakly positive respectively in hepatocellular carcinomas compared to stronger AGR3 positivity in cholangiocellular carcinomas. AGR3 expression statistically significantly correlated to acid mucopolysaccharide expression and negatively correlated to glypican-3 expression. We conclude that according to receiver operating characteristics (ROC) analysis AGR3 expression is relatively specific for ICC and is potentially linked to mucosecretion, which may indicate potential implication in treatment resistance." @default.
- W1999623745 created "2016-06-24" @default.
- W1999623745 creator A5017937179 @default.
- W1999623745 creator A5029034340 @default.
- W1999623745 creator A5034601455 @default.
- W1999623745 creator A5050370767 @default.
- W1999623745 creator A5054528818 @default.
- W1999623745 creator A5080594950 @default.
- W1999623745 creator A5081826214 @default.
- W1999623745 date "2014-06-01" @default.
- W1999623745 modified "2023-09-27" @default.
- W1999623745 title "Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma" @default.
- W1999623745 cites W1542194599 @default.
- W1999623745 cites W1979699580 @default.
- W1999623745 cites W1982427071 @default.
- W1999623745 cites W1989531492 @default.
- W1999623745 cites W1994919628 @default.
- W1999623745 cites W1997213888 @default.
- W1999623745 cites W1998948370 @default.
- W1999623745 cites W2035966539 @default.
- W1999623745 cites W2052545791 @default.
- W1999623745 cites W2062924862 @default.
- W1999623745 cites W2081341738 @default.
- W1999623745 cites W2086909288 @default.
- W1999623745 cites W2106787323 @default.
- W1999623745 cites W2129416856 @default.
- W1999623745 cites W2137052325 @default.
- W1999623745 cites W2137983743 @default.
- W1999623745 cites W2143571146 @default.
- W1999623745 cites W2146625285 @default.
- W1999623745 cites W4249551291 @default.
- W1999623745 doi "https://doi.org/10.1016/j.yexmp.2014.04.002" @default.
- W1999623745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24747240" @default.
- W1999623745 hasPublicationYear "2014" @default.
- W1999623745 type Work @default.
- W1999623745 sameAs 1999623745 @default.
- W1999623745 citedByCount "19" @default.
- W1999623745 countsByYear W19996237452015 @default.
- W1999623745 countsByYear W19996237452018 @default.
- W1999623745 countsByYear W19996237452019 @default.
- W1999623745 countsByYear W19996237452020 @default.
- W1999623745 countsByYear W19996237452021 @default.
- W1999623745 countsByYear W19996237452022 @default.
- W1999623745 countsByYear W19996237452023 @default.
- W1999623745 crossrefType "journal-article" @default.
- W1999623745 hasAuthorship W1999623745A5017937179 @default.
- W1999623745 hasAuthorship W1999623745A5029034340 @default.
- W1999623745 hasAuthorship W1999623745A5034601455 @default.
- W1999623745 hasAuthorship W1999623745A5050370767 @default.
- W1999623745 hasAuthorship W1999623745A5054528818 @default.
- W1999623745 hasAuthorship W1999623745A5080594950 @default.
- W1999623745 hasAuthorship W1999623745A5081826214 @default.
- W1999623745 hasConcept C121608353 @default.
- W1999623745 hasConcept C126322002 @default.
- W1999623745 hasConcept C142724271 @default.
- W1999623745 hasConcept C204232928 @default.
- W1999623745 hasConcept C2778019345 @default.
- W1999623745 hasConcept C2779742787 @default.
- W1999623745 hasConcept C2909135397 @default.
- W1999623745 hasConcept C502942594 @default.
- W1999623745 hasConcept C555283112 @default.
- W1999623745 hasConcept C71924100 @default.
- W1999623745 hasConcept C86803240 @default.
- W1999623745 hasConceptScore W1999623745C121608353 @default.
- W1999623745 hasConceptScore W1999623745C126322002 @default.
- W1999623745 hasConceptScore W1999623745C142724271 @default.
- W1999623745 hasConceptScore W1999623745C204232928 @default.
- W1999623745 hasConceptScore W1999623745C2778019345 @default.
- W1999623745 hasConceptScore W1999623745C2779742787 @default.
- W1999623745 hasConceptScore W1999623745C2909135397 @default.
- W1999623745 hasConceptScore W1999623745C502942594 @default.
- W1999623745 hasConceptScore W1999623745C555283112 @default.
- W1999623745 hasConceptScore W1999623745C71924100 @default.
- W1999623745 hasConceptScore W1999623745C86803240 @default.
- W1999623745 hasIssue "3" @default.
- W1999623745 hasLocation W19996237451 @default.
- W1999623745 hasLocation W19996237452 @default.
- W1999623745 hasOpenAccess W1999623745 @default.
- W1999623745 hasPrimaryLocation W19996237451 @default.
- W1999623745 hasRelatedWork W1499339123 @default.
- W1999623745 hasRelatedWork W2012899811 @default.
- W1999623745 hasRelatedWork W2117059884 @default.
- W1999623745 hasRelatedWork W2359319847 @default.
- W1999623745 hasRelatedWork W2365011556 @default.
- W1999623745 hasRelatedWork W2386104765 @default.
- W1999623745 hasRelatedWork W2388960036 @default.
- W1999623745 hasRelatedWork W3032621101 @default.
- W1999623745 hasRelatedWork W4323808922 @default.
- W1999623745 hasRelatedWork W4386105113 @default.
- W1999623745 hasVolume "96" @default.
- W1999623745 isParatext "false" @default.
- W1999623745 isRetracted "false" @default.
- W1999623745 magId "1999623745" @default.
- W1999623745 workType "article" @default.