FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999636391> ?p ?o ?g. }

• W1999636391 abstract "We used an unique model, human medullary thyroid carcinoma (MTC) in culture (the TT line), to study features of neuroendocrine-related biochemistry in relationship to growth, differentiation, and tumor progression. Tumor tissues from patients with virulent MTC contain a very heterogeneous distribution of cells staining for calcitonin (CT) and have a high ratio of intracellular L-dopa decarboxylase activity (DDC) to CT. We found, in a culture line of MTC derived from a patient with virulent disease, that the degree of the inverse relationship between DDC and CT and the heterogeneous cellular distribution of CT probably relate to the rate of cellular growth and the biochemical set of individual cell clones. During exponential growth of the parent TT cell line, intracellular DDC and CT varied. DDC increased by 70% and CT decreased by 40%. Single time-point measurements in 54 cell clones or highly enriched cell populations revealed a more dramatic variability for CT (15-fold) than for DDC (5-fold). During growth of the clones having the highest and lowest CT measurements, respectively, inverse dynamics between DDC and CT were again found. However, each clone maintained a distinct range of CT during the entire growth curve, with a 2- to 4-fold difference in CT between the two clones throughout. In the low producing CT clone, ratios between DDC and CT rose to greater than 1.0 during growth, a very high value found before this study only in MTC tissues from patients with virulent disease. Immunohistochemical staining for CT of parent cells and clones grown on embryonic chick skin revealed increased cellular heterogeneity for CT distribution during growth. The TT line provides a powerful tool to study neuroendocrine related biochemical events in relationship to growth, differentiation, and tumor progression in MTC. Our in vitro findings in the TT line well explain observations made previously in patients. We conclude that: (1) DDC, a neural property of MTC, is an early differentiation marker as compared to CT and that the differentiation status of MTC cells varies inversely with cell growth rate; and (2) in patients with MTC, the virulence of the tumor probably varies inversely with differentiation status. The inverse ratio of DDC to CT is probably determined in MTC by the proportion of rapidly growing cells and numbers of cell clones which have a poor ability for maturation." @default.
• W1999636391 created "2016-06-24" @default.
• W1999636391 creator A5015179016 @default.
• W1999636391 creator A5058612163 @default.
• W1999636391 creator A5066646736 @default.
• W1999636391 creator A5074796599 @default.
• W1999636391 creator A5075190799 @default.
• W1999636391 creator A5091781944 @default.
• W1999636391 creator A5040708399 @default.
• W1999636391 date "1984-08-01" @default.
• W1999636391 modified "2023-09-23" @default.
• W1999636391 title "Human Medullary Thyroid Carcinoma in Culture Provides a Model Relating Growth Dynamics, Endocrine Cell Differentiation, and Tumor Progression*" @default.
• W1999636391 cites W133676264 @default.
• W1999636391 cites W1572314162 @default.
• W1999636391 cites W1686625415 @default.
• W1999636391 cites W1775749144 @default.
• W1999636391 cites W1967304777 @default.
• W1999636391 cites W2016705667 @default.
• W1999636391 cites W2019778331 @default.
• W1999636391 cites W2021483262 @default.
• W1999636391 cites W2027363229 @default.
• W1999636391 cites W2030737367 @default.
• W1999636391 cites W2032552530 @default.
• W1999636391 cites W2034713890 @default.
• W1999636391 cites W2049353052 @default.
• W1999636391 cites W2055436487 @default.
• W1999636391 cites W2060512249 @default.
• W1999636391 cites W2085572755 @default.
• W1999636391 cites W2091225809 @default.
• W1999636391 cites W2094155281 @default.
• W1999636391 cites W2124663059 @default.
• W1999636391 cites W2135125272 @default.
• W1999636391 cites W2147806404 @default.
• W1999636391 cites W2152848856 @default.
• W1999636391 cites W2165740658 @default.
• W1999636391 cites W2274471144 @default.
• W1999636391 cites W2323916369 @default.
• W1999636391 cites W2340837163 @default.
• W1999636391 doi "https://doi.org/10.1210/jcem-59-2-338" @default.
• W1999636391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6736207" @default.
• W1999636391 hasPublicationYear "1984" @default.
• W1999636391 type Work @default.
• W1999636391 sameAs 1999636391 @default.
• W1999636391 citedByCount "55" @default.
• W1999636391 countsByYear W19996363912012 @default.
• W1999636391 countsByYear W19996363912013 @default.
• W1999636391 countsByYear W19996363912016 @default.
• W1999636391 countsByYear W19996363912019 @default.
• W1999636391 countsByYear W19996363912023 @default.
• W1999636391 crossrefType "journal-article" @default.
• W1999636391 hasAuthorship W1999636391A5015179016 @default.
• W1999636391 hasAuthorship W1999636391A5040708399 @default.
• W1999636391 hasAuthorship W1999636391A5058612163 @default.
• W1999636391 hasAuthorship W1999636391A5066646736 @default.
• W1999636391 hasAuthorship W1999636391A5074796599 @default.
• W1999636391 hasAuthorship W1999636391A5075190799 @default.
• W1999636391 hasAuthorship W1999636391A5091781944 @default.
• W1999636391 hasConcept C104317684 @default.
• W1999636391 hasConcept C121608353 @default.
• W1999636391 hasConcept C134018914 @default.
• W1999636391 hasConcept C142724271 @default.
• W1999636391 hasConcept C148738053 @default.
• W1999636391 hasConcept C1491633281 @default.
• W1999636391 hasConcept C2776667971 @default.
• W1999636391 hasConcept C2779627488 @default.
• W1999636391 hasConcept C2780120053 @default.
• W1999636391 hasConcept C2780192828 @default.
• W1999636391 hasConcept C2780341458 @default.
• W1999636391 hasConcept C2993294228 @default.
• W1999636391 hasConcept C48900799 @default.
• W1999636391 hasConcept C526584372 @default.
• W1999636391 hasConcept C54355233 @default.
• W1999636391 hasConcept C552990157 @default.
• W1999636391 hasConcept C55493867 @default.
• W1999636391 hasConcept C62112901 @default.
• W1999636391 hasConcept C71924100 @default.
• W1999636391 hasConcept C81089528 @default.
• W1999636391 hasConcept C81885089 @default.
• W1999636391 hasConcept C85813293 @default.
• W1999636391 hasConcept C86803240 @default.
• W1999636391 hasConceptScore W1999636391C104317684 @default.
• W1999636391 hasConceptScore W1999636391C121608353 @default.
• W1999636391 hasConceptScore W1999636391C134018914 @default.
• W1999636391 hasConceptScore W1999636391C142724271 @default.
• W1999636391 hasConceptScore W1999636391C148738053 @default.
• W1999636391 hasConceptScore W1999636391C1491633281 @default.
• W1999636391 hasConceptScore W1999636391C2776667971 @default.
• W1999636391 hasConceptScore W1999636391C2779627488 @default.
• W1999636391 hasConceptScore W1999636391C2780120053 @default.
• W1999636391 hasConceptScore W1999636391C2780192828 @default.
• W1999636391 hasConceptScore W1999636391C2780341458 @default.
• W1999636391 hasConceptScore W1999636391C2993294228 @default.
• W1999636391 hasConceptScore W1999636391C48900799 @default.
• W1999636391 hasConceptScore W1999636391C526584372 @default.
• W1999636391 hasConceptScore W1999636391C54355233 @default.
• W1999636391 hasConceptScore W1999636391C552990157 @default.
• W1999636391 hasConceptScore W1999636391C55493867 @default.
• W1999636391 hasConceptScore W1999636391C62112901 @default.
• W1999636391 hasConceptScore W1999636391C71924100 @default.
• W1999636391 hasConceptScore W1999636391C81089528 @default.

• next