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- W1999647591 abstract "Conformational analyses of PRP1, a proline-rich acidic salivary protein and major component of the acquired enamel pellicle, have been carried out in solution and upon binding to two enamel prototypes, hydroxyapatite (HA) and carbonated hydroxyapatite (CHA), using Fourier transform infrared spectroscopy (FTIR) in attenuated total reflection (ATR) mode. We have shown for the first time that, in solution, large portions of PRP1 adopt the hydrated polyproline type II (PPII) helical structure in addition to the random coil structure, with the maximum absorbance of the amide I band around 1620 cm-1. Upon binding to HA or CHA, the protein undergoes significant conformational changes, loosing a considerable portion of hydrated PPII and random coil domains with a shift in the maximum absorbance to 1666 cm-1, indicating that a large fraction of the protein is composed of β turns. A small fraction of PPII in a calcium-bound or anhydrous form (∼1642 cm-1) was also observed in the HA- and CHA-bound proteins, which could play a role in protein−mineral interactions. The conformational changes in PRP1 adsorbed on CHA and HA were similar in nature; however, these changes were greater in the protein bound to HA. Interestingly, these results are in agreement with protein adsorption data that show that less protein is adsorbed onto CHA than onto HA. Our results demonstrate that binding to apatitic mineral surfaces leads to major conformational changes in PRP1, which might reflect the expulsion of water and the formation of protein−mineral and/or protein−protein interactions in the adsorbed layer." @default.
- W1999647591 created "2016-06-24" @default.
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- W1999647591 creator A5084093578 @default.
- W1999647591 date "2007-09-20" @default.
- W1999647591 modified "2023-09-26" @default.
- W1999647591 title "Conformational Changes in Salivary Proline-Rich Protein 1 upon Adsorption to Calcium Phosphate Crystals" @default.
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- W1999647591 doi "https://doi.org/10.1021/la7013978" @default.
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