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• W1999653164 abstract "The PEA3 group of transcription factors belongs to the Ets family and is composed of PEA3, ERM, and ER81, which are more than 95% identical within the DNA-binding domain—the ETS domain—and which demonstrate 50% aa identity overall. We present here a review of the current knowledge of these transcription factors, which possess functional domains responsible for DNA-binding, DNA-binding inhibition, and transactivation. Recent data suggest that these factors are targets for signaling cascades, such as the Ras-dependent ones, and thus may contribute first to the nuclear response to cell stimulation and second to Ras-induced cell transformation. The expression of the PEA3 group members in numerous developing murine organs, and, especially, in epithelial–mesenchymal interaction events, suggests a key role in murine organogenesis. Moreover, their expression in certain breast cancer cells suggests a possible involvement of these genes in the appearance, progression, and invasion of malignant cells." @default.
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• W1999653164 date "1997-08-01" @default.
• W1999653164 modified "2023-10-17" @default.
• W1999653164 title "Structure–Function Relationships of the PEA3 Group of Ets-Related Transcription Factors" @default.
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• W1999653164 doi "https://doi.org/10.1006/bmme.1997.2605" @default.
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