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- W1999653236 endingPage "S159" @default.
- W1999653236 startingPage "S152" @default.
- W1999653236 abstract "Development of acute, severe thrombocytopenia has been reported in several patients treated with a chimeric monoclonal antibody fragment to the platelet glycoprotein IIb/IIIa (GPIIb/IIIa) complex. However, the propensity of oral GPIIb/IIIa antagonists to induce antibody-mediated thrombocytopenia or platelet dysfunction with chronic exposure is unknown. There is evidence to suggest that a small percentage of otherwise healthy individuals have preexisting serum antibodies to conformation-dependent epitopes in the GPIIb/IIIa complex that are induced by certain members of this class of compounds that function as mixed agonists/antagonists. Additional studies are needed to identify the epitopes recognized by these antibodies and the requirement for the drug or a drug-metabolite to be present for antibody binding and detection. Detailed immunologic studies of antibodies from patients in whom immune thrombocytopenia develops after receiving oral GPIIb/IIIa antagonists may also provide insight into the mechanism by which activated platelets are normally cleared from the circulation." @default.
- W1999653236 created "2016-06-24" @default.
- W1999653236 creator A5077478635 @default.
- W1999653236 date "1998-05-01" @default.
- W1999653236 modified "2023-10-18" @default.
- W1999653236 title "Glycoprotein IIb/IIIa antagonists: Potential induction and detection of drug-dependent antiplatelet antibodies" @default.
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- W1999653236 doi "https://doi.org/10.1016/s0002-8703(98)70243-1" @default.
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