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• W1999674210 abstract "Abstract Signal transducer and activator of transcription 3 ( STAT 3) dramatically increases during the first post‐natal week, and supports the survival of mature hippocampal neurons. Recently, we reported that chronic elevation of excitability leads to a loss of STAT 3 signal, inducing vulnerability in neurons. The loss of STAT 3 signal was due to impaired E rk1/2 activation. While overnight elevation of activity attenuated STAT 3 signal, brief low‐frequency stimuli, which induce long‐term depression, have been shown to activate STAT 3. Here we investigated how STAT 3 responds to depolarization in mature neurons. A brief depolarization results in the transient activation of STAT 3: it induces calcium influx through L ‐type voltage‐gated calcium channels, which triggers activation of S rc family kinases. Src family kinases are required for phosphorylation of STAT 3 at T yr‐705 and S er‐727. PT yr‐705 is Janus kinase ( JAK )‐dependent, while PS er‐727 is dependent on A kt, the S er/ T hr kinase. Both PT yr‐705 and PS er‐727 are necessary for nuclear translocation of STAT 3 in these neurons. Chronic elevation of spontaneous activity by an A‐type potassium blocker, 4‐aminopyridine (4‐ AP ), also induced the transient phosphorylation of STAT 3, which after 4 h fell to basal levels despite the presence of 4‐ AP . These results suggest that phasic and chronic neuronal activation induce distinct molecular pathways, resulting in opposing regulation of STAT 3 signal." @default.
• W1999674210 created "2016-06-24" @default.
• W1999674210 creator A5050613284 @default.
• W1999674210 creator A5055872472 @default.
• W1999674210 date "2013-11-06" @default.
• W1999674210 modified "2023-10-03" @default.
• W1999674210 title "Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons" @default.
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• W1999674210 doi "https://doi.org/10.1111/ejn.12412" @default.
• W1999674210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24199834" @default.
• W1999674210 hasPublicationYear "2013" @default.
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