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• W1999680455 abstract "Evidence for an increased prevalence of BRAFV600E mutations has been documented in recent decades. The aim of this study was to evaluate the prevalence of both RET/PTC rearrangements and BRAFV600E mutations in an Italian cohort of papillary thyroid carcinoma (PTC) patients followed at the Endocrine Units of Pisa, Milano, and Perugia from 1996–2010. In total, 401 PTC patients were examined and grouped according to the time of surgery: group 1, 1996–2000; group 2, 2001–2005; and group 3, 2006–2010. Patients were analyzed for clinical, pathological, and molecular features. In parallel, the molecular characteristics of 459 PTC from Sicily were studied. The genetic profiles of the three groups were significantly different (P < 0.0001). In particular, the frequency of RET/PTC rearrangements decreased from 1996–2010, occurring in 33 of 100 (33%) of the patients in group 1, 26 of 148 (17%) in group 2, and 15 of 153 (9.8%) in group 3. The incidence of BRAFV600E mutations increased over the same period, from 28% in group 1 (28 of 100) to 48.9% in group 2 (73 of 148) and 58.1% in group 3 (89 of 153). A consistent increase in BRAFV600E prevalence was observed in the Sicilian group (P < 0.0001). Moreover, a statistically significant increase in the mean age at diagnosis and decrease in tumor size over the study period was observed. The genetic profile of PTC changed over the last 15 yr, with a significant decrease in the prevalence of RET/PTC rearrangements and an increase in BRAFV600E mutations. In addition, the mean age at diagnosis increased and tumor size decreased over the study period." @default.
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• W1999680455 date "2012-09-01" @default.
• W1999680455 modified "2023-09-27" @default.
• W1999680455 title "Modifications in the Papillary Thyroid Cancer Gene Profile Over the Last 15 Years" @default.
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• W1999680455 doi "https://doi.org/10.1210/jc.2012-1269" @default.
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