Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999692874> ?p ?o ?g. }
- W1999692874 endingPage "70" @default.
- W1999692874 startingPage "62" @default.
- W1999692874 abstract "We studied the viability of Plasmodium falciparum parasites reappearing in long-term cultures after repetitive exposure to atovaquone and proguanil. Parasites (F32 and FCR3) exposed to 100-5000 nM atovaquone for 96 hours were reduced to <5% of initial parasitaemia but recrudesced after 9-15 days. Also, parasites exposed to 1000 nM atovaquone for 48, 72, 96 and 144 hours recrudesced after 9, 14, 21 and 23 days respectively. Immediately after removal of the drug, only 1-3 schizonts per 10000 red blood cells were found consistently, apparently unable to produce trophozoites and thus, possibly, adopting a dormant state. Parasites (F32 and FCR3) exposed to 500 nM atovaquone for 72 hours reappeared after 14 days. These recrudescing parasites were then re-exposed and suppressed by atovaquone in three consecutive follow-up experiments. They reappeared after 12, 11 and 9 days respectively. No known point mutations in cytochrome b gene (cytb), associated with atovaquone resistance, were detected in any recrudescing parasites. Finally, parasites (F32) exposed to various concentrations of atovaquone and proguanil in combination for 72 hours reappeared after 9-17 days. The baseline susceptibilities of the parasites to individual drugs were similar before and after recrudescence in all experiments." @default.
- W1999692874 created "2016-06-24" @default.
- W1999692874 creator A5000301162 @default.
- W1999692874 creator A5003004700 @default.
- W1999692874 creator A5063465178 @default.
- W1999692874 date "2005-01-01" @default.
- W1999692874 modified "2023-09-30" @default.
- W1999692874 title "In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil" @default.
- W1999692874 cites W1813231790 @default.
- W1999692874 cites W1935016814 @default.
- W1999692874 cites W1966263393 @default.
- W1999692874 cites W1969503178 @default.
- W1999692874 cites W1971113428 @default.
- W1999692874 cites W1988473164 @default.
- W1999692874 cites W2006876655 @default.
- W1999692874 cites W2007561244 @default.
- W1999692874 cites W2011824976 @default.
- W1999692874 cites W2018521635 @default.
- W1999692874 cites W2023939332 @default.
- W1999692874 cites W2031645951 @default.
- W1999692874 cites W2036009917 @default.
- W1999692874 cites W2041866493 @default.
- W1999692874 cites W2055527040 @default.
- W1999692874 cites W2057168426 @default.
- W1999692874 cites W2063256018 @default.
- W1999692874 cites W2068803721 @default.
- W1999692874 cites W2076329739 @default.
- W1999692874 cites W2085832074 @default.
- W1999692874 cites W2089337157 @default.
- W1999692874 cites W2090585008 @default.
- W1999692874 cites W2091016659 @default.
- W1999692874 cites W2093038105 @default.
- W1999692874 cites W2093486072 @default.
- W1999692874 cites W2096616551 @default.
- W1999692874 cites W2100463889 @default.
- W1999692874 cites W2101397647 @default.
- W1999692874 cites W2102343384 @default.
- W1999692874 cites W2109766515 @default.
- W1999692874 cites W2128208738 @default.
- W1999692874 cites W2138488546 @default.
- W1999692874 cites W2145537179 @default.
- W1999692874 cites W2149706216 @default.
- W1999692874 cites W2166721999 @default.
- W1999692874 cites W2332417323 @default.
- W1999692874 cites W2344075384 @default.
- W1999692874 cites W2403020561 @default.
- W1999692874 cites W2403514952 @default.
- W1999692874 doi "https://doi.org/10.1016/j.trstmh.2004.01.016" @default.
- W1999692874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15550263" @default.
- W1999692874 hasPublicationYear "2005" @default.
- W1999692874 type Work @default.
- W1999692874 sameAs 1999692874 @default.
- W1999692874 citedByCount "26" @default.
- W1999692874 countsByYear W19996928742012 @default.
- W1999692874 countsByYear W19996928742013 @default.
- W1999692874 countsByYear W19996928742015 @default.
- W1999692874 countsByYear W19996928742016 @default.
- W1999692874 countsByYear W19996928742017 @default.
- W1999692874 countsByYear W19996928742020 @default.
- W1999692874 countsByYear W19996928742022 @default.
- W1999692874 countsByYear W19996928742023 @default.
- W1999692874 crossrefType "journal-article" @default.
- W1999692874 hasAuthorship W1999692874A5000301162 @default.
- W1999692874 hasAuthorship W1999692874A5003004700 @default.
- W1999692874 hasAuthorship W1999692874A5063465178 @default.
- W1999692874 hasConcept C136764020 @default.
- W1999692874 hasConcept C203014093 @default.
- W1999692874 hasConcept C2778048844 @default.
- W1999692874 hasConcept C2778371730 @default.
- W1999692874 hasConcept C2779124865 @default.
- W1999692874 hasConcept C2779636613 @default.
- W1999692874 hasConcept C41008148 @default.
- W1999692874 hasConcept C71924100 @default.
- W1999692874 hasConcept C71928629 @default.
- W1999692874 hasConcept C86803240 @default.
- W1999692874 hasConcept C89423630 @default.
- W1999692874 hasConcept C98274493 @default.
- W1999692874 hasConceptScore W1999692874C136764020 @default.
- W1999692874 hasConceptScore W1999692874C203014093 @default.
- W1999692874 hasConceptScore W1999692874C2778048844 @default.
- W1999692874 hasConceptScore W1999692874C2778371730 @default.
- W1999692874 hasConceptScore W1999692874C2779124865 @default.
- W1999692874 hasConceptScore W1999692874C2779636613 @default.
- W1999692874 hasConceptScore W1999692874C41008148 @default.
- W1999692874 hasConceptScore W1999692874C71924100 @default.
- W1999692874 hasConceptScore W1999692874C71928629 @default.
- W1999692874 hasConceptScore W1999692874C86803240 @default.
- W1999692874 hasConceptScore W1999692874C89423630 @default.
- W1999692874 hasConceptScore W1999692874C98274493 @default.
- W1999692874 hasIssue "1" @default.
- W1999692874 hasLocation W19996928741 @default.
- W1999692874 hasLocation W19996928742 @default.
- W1999692874 hasOpenAccess W1999692874 @default.
- W1999692874 hasPrimaryLocation W19996928741 @default.
- W1999692874 hasRelatedWork W175899902 @default.
- W1999692874 hasRelatedWork W1901559508 @default.
- W1999692874 hasRelatedWork W1995852503 @default.
- W1999692874 hasRelatedWork W2000230526 @default.